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In a study consisting of more than 180,000 male veterans aged 55 and older, those diagnosed with PTSD had nearly 2-fold the risk of developing dementia syndromes such as Alzheimer disease, frontotemporal dementia, Lewy Body dementia, vascular dementia, and senile dementia compared to those without PTSD.

[URL unfurl="true"]https://www.psychiatryadvisor.com/home/topics/anxiety/ptsd-trauma-and-stressor-related/expert-q-and-a-on-ptsd-and-dementia-risk/#:~:text=In%20a%20study%20consisting%20of,compared%20to%20those%20without%20PTSD.[/URL]

In this cohort study of 12 270 trauma-exposed middle-aged women, individuals with high levels of PTSD symptoms experienced significantly worse cognitive decline in learning and working memory as well as psychomotor speed and attention compared with those with no PTSD symptoms. These findings were not fully explained by demographic characteristics, behavioral factors, or health conditions, including comorbid depression.

[URL unfurl="true"]https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793794[/URL]

n conclusion, results from this study clarify the relationship between PTSD and cognitive function in a sample of Vietnam Veterans. Specifically, our results suggest that PTSD symptom severity has been associated with decline in cognitive function in two frequently used cognitive screeners. These results were significant even after adjusting for the influence of biomarkers implicated in AD pathology. Moreover, PTSD symptom severity showed the greatest relationship with declines in memory and attention. These results underscore the impact of chronic stress on cognition in older adults and the importance of managing symptoms of chronic stress among older adults. Moreover, this information can help identify individuals who may benefit most from interventions meant to prevent AD. Additionally, these research findings may be used to help monitor individuals at risk and help inform treatment plans.

Posttraumatic stress symptom severity predicts cognitive decline beyond the effect of Alzheimerâ€™s disease biomarkers in Veterans - Translational Psychiatry

<blockquote data-quote="Nelson Vergel" data-source="post: 260481" data-attributes="member: 3">In a study consisting of more than 180,000 male veterans aged 55 and older, those diagnosed with PTSD had nearly 2-fold the risk of developing dementia syndromes such as Alzheimer disease, frontotemporal dementia, Lewy Body dementia, vascular dementia, and senile dementia compared to those without PTSD.[URL unfurl=&quot;true&quot;]https://www.psychiatryadvisor.com/home/topics/anxiety/ptsd-trauma-and-stressor-related/expert-q-and-a-on-ptsd-and-dementia-risk/#:~:text=In%20a%20study%20consisting%20of,compared%20to%20those%20without%20PTSD.[/URL]In this cohort study of 12 270 trauma-exposed middle-aged women, individuals with high levels of PTSD symptoms experienced significantly worse cognitive decline in learning and working memory as well as psychomotor speed and attention compared with those with no PTSD symptoms. These findings were not fully explained by demographic characteristics, behavioral factors, or health conditions, including comorbid depression.[URL unfurl=&quot;true&quot;]https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793794[/URL]n conclusion, results from this study clarify the relationship between PTSD and cognitive function in a sample of Vietnam Veterans. Specifically, our results suggest that PTSD symptom severity has been associated with decline in cognitive function in two frequently used cognitive screeners. These results were significant even after adjusting for the influence of biomarkers implicated in AD pathology. Moreover, PTSD symptom severity showed the greatest relationship with declines in memory and attention. These results underscore the impact of chronic stress on cognition in older adults and the importance of managing symptoms of chronic stress among older adults. Moreover, this information can help identify individuals who may benefit most from interventions meant to prevent AD. Additionally, these research findings may be used to help monitor individuals at risk and help inform treatment plans.&nbsp;<a href="https://www.nature.com/articles/s41398-023-02354-0" target="_blank">Posttraumatic stress symptom severity predicts cognitive decline beyond the effect of Alzheimerâ€™s disease biomarkers in Veterans - Translational Psychiatry</a></blockquote>

[QUOTE="Nelson Vergel, post: 260481, member: 3"] In a study consisting of more than 180,000 male veterans aged 55 and older, those diagnosed with PTSD had nearly 2-fold the risk of developing dementia syndromes such as Alzheimer disease, frontotemporal dementia, Lewy Body dementia, vascular dementia, and senile dementia compared to those without PTSD. [URL unfurl="true"]https://www.psychiatryadvisor.com/home/topics/anxiety/ptsd-trauma-and-stressor-related/expert-q-and-a-on-ptsd-and-dementia-risk/#:~:text=In%20a%20study%20consisting%20of,compared%20to%20those%20without%20PTSD.[/URL] In this cohort study of 12 270 trauma-exposed middle-aged women, individuals with high levels of PTSD symptoms experienced significantly worse cognitive decline in learning and working memory as well as psychomotor speed and attention compared with those with no PTSD symptoms. These findings were not fully explained by demographic characteristics, behavioral factors, or health conditions, including comorbid depression. [URL unfurl="true"]https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2793794[/URL] n conclusion, results from this study clarify the relationship between PTSD and cognitive function in a sample of Vietnam Veterans. Specifically, our results suggest that PTSD symptom severity has been associated with decline in cognitive function in two frequently used cognitive screeners. These results were significant even after adjusting for the influence of biomarkers implicated in AD pathology. Moreover, PTSD symptom severity showed the greatest relationship with declines in memory and attention. These results underscore the impact of chronic stress on cognition in older adults and the importance of managing symptoms of chronic stress among older adults. Moreover, this information can help identify individuals who may benefit most from interventions meant to prevent AD. Additionally, these research findings may be used to help monitor individuals at risk and help inform treatment plans. [URL="https://www.nature.com/articles/s41398-023-02354-0"]Posttraumatic stress symptom severity predicts cognitive decline beyond the effect of Alzheimerâ€™s disease biomarkers in Veterans - Translational Psychiatry[/URL] [/QUOTE]

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038