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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
PT-141 Users? Time of Day & Efficacy
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<blockquote data-quote="JPB" data-source="post: 44613" data-attributes="member: 2659"><p>Vince, let me try to clue you in as to why my post and observations regarding Melanotan II are relevant to the posters question. Melanotan II and PT-141 are both melanocortin agonists. Indirectly they are dopamine agonists. PT-141 was developed from Melanotan II in an attempt to isolate the erection and libido stimulating effects. So its pharmacodynamics are classified as more potent, and more selective in this regard. In actual research, your mileage may vary. So, PT-141 does not stimulate to the same degree the MC1 receptors that result in hyperpigmentation (and tanning) effect of Melanotan II. However, the means by which both stimulate erections is the same, and it is through neurologic modulation of MC receptors.</p><p></p><p>Now, the observation that these products work at their best to induce morning wood are not unique to this thread. You will see others report similar research findings. I will venture a theory on why this is the case. Getting an erection is neurologically induced by parasympathetic nerves. Since these products work on neurologic levels, the effect is most likely to provide the necessary parasympathetic lift to lead to an erection when our bodies are already in parasympathetic shift (during rest or deep sleep). The timing of the effect is usually observed to be about 6-7 hours, fairly closely coinciding with the deeper sleep cycles and the natural circadian timing of morning wood.</p><p></p><p>So that's why I contributed to the thread. I'm not looking for any credit but would like to avoid ignorant unnecessary remarks. I hope this helps explain things to those that are a bit too quick to criticize.</p></blockquote><p></p>
[QUOTE="JPB, post: 44613, member: 2659"] Vince, let me try to clue you in as to why my post and observations regarding Melanotan II are relevant to the posters question. Melanotan II and PT-141 are both melanocortin agonists. Indirectly they are dopamine agonists. PT-141 was developed from Melanotan II in an attempt to isolate the erection and libido stimulating effects. So its pharmacodynamics are classified as more potent, and more selective in this regard. In actual research, your mileage may vary. So, PT-141 does not stimulate to the same degree the MC1 receptors that result in hyperpigmentation (and tanning) effect of Melanotan II. However, the means by which both stimulate erections is the same, and it is through neurologic modulation of MC receptors. Now, the observation that these products work at their best to induce morning wood are not unique to this thread. You will see others report similar research findings. I will venture a theory on why this is the case. Getting an erection is neurologically induced by parasympathetic nerves. Since these products work on neurologic levels, the effect is most likely to provide the necessary parasympathetic lift to lead to an erection when our bodies are already in parasympathetic shift (during rest or deep sleep). The timing of the effect is usually observed to be about 6-7 hours, fairly closely coinciding with the deeper sleep cycles and the natural circadian timing of morning wood. So that's why I contributed to the thread. I'm not looking for any credit but would like to avoid ignorant unnecessary remarks. I hope this helps explain things to those that are a bit too quick to criticize. [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
PT-141 Users? Time of Day & Efficacy
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