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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
PSA numbers increasing on testosterone- Should I stop TRT?
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<blockquote data-quote="Scors60" data-source="post: 164228" data-attributes="member: 1465"><p>Well, my fortunes have certainly changed since my previous post from 2014 on this thread. I had a fluctuating PSA for over a year. 2.5 to 6.1 and back down and back up. I'm 65. My Urologist finally ordered an MRI for me. Unfortunately, it came back with 3 spots, one with a PIRADS 4 and two with PIRADS 3. A 4 indicates most likely cancer, a 3 might be, might not. With that, I stopped TRT and had a biopsy performed. Sure enough, that small spot at PIRADS 4 ended up being a lesion with a Gleason score of 3+4 (intermediate risk cancer). I am now deciding on treatment, will probably go with Cyberknife.</p><p></p><p>Although my Uro agrees with me that it was NOT the TRT that caused the cancer, the jury is, frankly, out on whether or not it can feed an existing cancer. That is why I stopped and, to tell you the truth, after 3 months plus off cold turkey, I still feel OK--I mean, I can notice certain differences, but it is nowhere near the living hell I was expecting. I am quite sure my T is back down to where it was when I was first diagnosed 6 years ago (180) or possibly lower, so any suggestion of Androgen Deprivation as a treatment is automatically off the table for me.</p><p></p><p>My Uro has said that, after I am treated and show a year of consistently low PSA and no findings via MRI or follow up biopsy, he would begin to treat me with TRT again if I so wished. He's on it himself, so he knows the deal. As I would be nearing 70 at that point, I will have to see if I want to.</p><p></p><p>My point is, don't f#@k around with this. If you have suspicions, and you are over 45, get whatever test you need to at least rule it out. Even if you DO have it, if it is caught early and you get treated, you can still go back to TRT if you want to. I had zero indicators that this would happen other than that bouncing PSA--each of those tests was a 4K, and each said I had a 4 to 7 percent chance of finding cancer on biopsy, which is very low risk. Oops. Surprise.</p><p></p><p>If you are younger than 45, I doubt you have to worry, especially since you are still in the normal range and your free PSA is very high (that's a good thing). But guys over 45, if it starts to creep steadily up, especially if you have a family history or are in a profile group with higher risk (African American men are at much higher risk, for example), please get yourself checked if for nothing else to rule it out. It takes a long time to develop and grow and prognosis for 10 or 15 year survival is excellent, but if you just ignore it, you're playing Russian Roulette with 3 bullets in the chambers.</p></blockquote><p></p>
[QUOTE="Scors60, post: 164228, member: 1465"] Well, my fortunes have certainly changed since my previous post from 2014 on this thread. I had a fluctuating PSA for over a year. 2.5 to 6.1 and back down and back up. I'm 65. My Urologist finally ordered an MRI for me. Unfortunately, it came back with 3 spots, one with a PIRADS 4 and two with PIRADS 3. A 4 indicates most likely cancer, a 3 might be, might not. With that, I stopped TRT and had a biopsy performed. Sure enough, that small spot at PIRADS 4 ended up being a lesion with a Gleason score of 3+4 (intermediate risk cancer). I am now deciding on treatment, will probably go with Cyberknife. Although my Uro agrees with me that it was NOT the TRT that caused the cancer, the jury is, frankly, out on whether or not it can feed an existing cancer. That is why I stopped and, to tell you the truth, after 3 months plus off cold turkey, I still feel OK--I mean, I can notice certain differences, but it is nowhere near the living hell I was expecting. I am quite sure my T is back down to where it was when I was first diagnosed 6 years ago (180) or possibly lower, so any suggestion of Androgen Deprivation as a treatment is automatically off the table for me. My Uro has said that, after I am treated and show a year of consistently low PSA and no findings via MRI or follow up biopsy, he would begin to treat me with TRT again if I so wished. He's on it himself, so he knows the deal. As I would be nearing 70 at that point, I will have to see if I want to. My point is, don't f#@k around with this. If you have suspicions, and you are over 45, get whatever test you need to at least rule it out. Even if you DO have it, if it is caught early and you get treated, you can still go back to TRT if you want to. I had zero indicators that this would happen other than that bouncing PSA--each of those tests was a 4K, and each said I had a 4 to 7 percent chance of finding cancer on biopsy, which is very low risk. Oops. Surprise. If you are younger than 45, I doubt you have to worry, especially since you are still in the normal range and your free PSA is very high (that's a good thing). But guys over 45, if it starts to creep steadily up, especially if you have a family history or are in a profile group with higher risk (African American men are at much higher risk, for example), please get yourself checked if for nothing else to rule it out. It takes a long time to develop and grow and prognosis for 10 or 15 year survival is excellent, but if you just ignore it, you're playing Russian Roulette with 3 bullets in the chambers. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
PSA numbers increasing on testosterone- Should I stop TRT?
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