Frankly, your care has been substandard. I would go so far to say that testosterone replacement didn't fail you, your doctor failed you by not testing properly during your efforts with exogenous testosterone. Sex Hormone Binding Globulin levels determine how often and how much testosterone should be injected. The research is clear - smaller, more frequent injections will typically lead to success (50-60mg every 3.5 days is a typical starting protocol). Adjustments, based on SHBG (the higher that value the fewer injections per week are needed - typically), help sort things out. We've members who inject on an EOD basis, and a very few of us inject every morning. The more frequently one injects, the less testosterone is needed to achieve solid levels and the risk of estradiol peaking is minimized as well.
But that's past history in your case. You have had success in boosting levels with Clomid. But by not running estradiol tests, your doctor has fallen into a trap, and taken you with him, undermining your efforts. Clomid sends estradiol, estrogen-2, upward. Too much estradiol weakens erections, washes libido out, and can cause water retention and weight gain. Estradiol is a very important hormone for men - but not in excess.
I would test free testosterone, estradiol/sensitive, DHT, and prolactin. These may help you solve the puzzle you've been presented. Were they they run before you started your initial therapy? Was a full thyroid panel obtained?
