ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
PROSPECTS FOR FSH TREATMENT OF MALE INFERTILITY
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 187953" data-attributes="member: 13851"><p>[ATTACH=full]10891[/ATTACH]</p><p><strong>Figure 1. <span style="color: rgb(184, 49, 47)">FSHR-mediated intracellular events in human Sertoli cells.</span> Hormone binding to the receptor leads to the activation of multiple signaling pathways triggered by Gα proteins and G βγ complex, as well as β-arrestins and adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 <span style="color: rgb(184, 49, 47)">(APPL1)</span>. Gαs protein activation mediates proliferative signals via ERK1/2 and the transcription factor CREB, although the intracellular cAMP increase and PKA activation, occurring upstream, are linked to p38 MAPK-dependent cell death. Its inhibition is due to the action of ERK1/2, that is activated also by other Gα proteins and β-arrestins, which, in turn, leads to FSHR internalization, while APPL1 and the βγ dimer induces cell survival signals.</strong></p></blockquote><p></p>
[QUOTE="madman, post: 187953, member: 13851"] [ATTACH type="full"]10891[/ATTACH] [B]Figure 1. [COLOR=rgb(184, 49, 47)]FSHR-mediated intracellular events in human Sertoli cells.[/COLOR] Hormone binding to the receptor leads to the activation of multiple signaling pathways triggered by Gα proteins and G βγ complex, as well as β-arrestins and adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 [COLOR=rgb(184, 49, 47)](APPL1)[/COLOR]. Gαs protein activation mediates proliferative signals via ERK1/2 and the transcription factor CREB, although the intracellular cAMP increase and PKA activation, occurring upstream, are linked to p38 MAPK-dependent cell death. Its inhibition is due to the action of ERK1/2, that is activated also by other Gα proteins and β-arrestins, which, in turn, leads to FSHR internalization, while APPL1 and the βγ dimer induces cell survival signals.[/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
PROSPECTS FOR FSH TREATMENT OF MALE INFERTILITY
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top