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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Propionate PIP Poll
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<blockquote data-quote="FunkOdyssey" data-source="post: 232129" data-attributes="member: 44064"><p>Very interesting [USER=38590]@readalot[/USER], thank you. Instead of calling it "testosterone crashing out of solution in the body", we can now use the medical terminology of post-injection drug precipitation (PDP). The articles you've posted offer a couple possible explanations for how this PDP could occur, even if the concentration of testosterone propionate in the vial is not excessive to begin with:</p><ol> <li data-xf-list-type="ol">The dilution curve of the formulation may intersect the solubility line as the solution is diluted with bodily fluids and cause precipitation.</li> <li data-xf-list-type="ol">Solvents may be absorbed faster than the drug, causing the remaining solution to become supersaturated.</li> <li data-xf-list-type="ol">There might be a third possibility involving acid-base reactions that is beyond my understanding.</li> </ol><p>I think this neatly ties together both theories about the cause of test propionate PIP: that the concentration is too high or that it is caused by improper selection and amounts of non-oil additives. Either of those individually, or both together, could cause PDP to occur. The expertise of the compounding pharmacy could certainly make a difference -- UGL products may be more prone to PDP due to poor judgment of the formulator.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 232129, member: 44064"] Very interesting [USER=38590]@readalot[/USER], thank you. Instead of calling it "testosterone crashing out of solution in the body", we can now use the medical terminology of post-injection drug precipitation (PDP). The articles you've posted offer a couple possible explanations for how this PDP could occur, even if the concentration of testosterone propionate in the vial is not excessive to begin with: [LIST=1] [*]The dilution curve of the formulation may intersect the solubility line as the solution is diluted with bodily fluids and cause precipitation. [*]Solvents may be absorbed faster than the drug, causing the remaining solution to become supersaturated. [*]There might be a third possibility involving acid-base reactions that is beyond my understanding. [/LIST] I think this neatly ties together both theories about the cause of test propionate PIP: that the concentration is too high or that it is caused by improper selection and amounts of non-oil additives. Either of those individually, or both together, could cause PDP to occur. The expertise of the compounding pharmacy could certainly make a difference -- UGL products may be more prone to PDP due to poor judgment of the formulator. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Propionate PIP Poll
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