We studied 1,025 community-dwelling men median age 75.1 years at baseline with 8.6 years follow-up. Baseline and follow-up T, DHT and E2 were assayed using mass spectrometry. Physical performance was assessed at follow-up. Correlations and covariate-adjusted P-values were determined. Longitudinal change in T was -2.0%/year, DHT -7.2%/year, LH +7.5%/year, SHBG +5.6%/year while E2 remained stable. Higher baseline T correlated with better physical performance at follow-up. Larger annualised increases in LH predicted poorer physical performance at follow-up.
