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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progestogen-mediated neuroprotection in central nervous system disorders
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<blockquote data-quote="madman" data-source="post: 227022" data-attributes="member: 13851"><p><strong>Figure 2: <u>Mechanisms of action of progesterone and allopregnanolone on the Central Nervous System</u>. Two main pathways mediate the effects of progesterone on target cells: the classical (canonic pathway) and non-classical (non-canonic pathway). In the classical signaling pathway, both progesterone and 5α-dihydroprogesterone (5αDHP) bind to intracellular progesterone receptors (PR), which dimerize and translocate to the nucleus, thus interacting with the regulatory progesterone response elements (PRE) in the DNA, which regulates the expression of specific genes. While in the non-classical pathway, there is an activation of G protein-coupled membrane progesterone receptors (mPRs) and progesterone receptor membrane component 1 (PGRMC1), leading to activation of MAPK, protein kinase C (PKC), and PI3K / Akt pathways. 5α-dihydroprogesterone is converted to allopregnanolone. The latter has no affinity for PR but is a positive modulator of type A γ-aminobutyric acid receptors (GABAA) and is also a ligand for mPRs. MBP: myelin basic protein, ∆ᴪm: mitochondrial membrane potential.</strong></p><p><strong>[ATTACH=full]23200[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 227022, member: 13851"] [B]Figure 2: [U]Mechanisms of action of progesterone and allopregnanolone on the Central Nervous System[/U]. Two main pathways mediate the effects of progesterone on target cells: the classical (canonic pathway) and non-classical (non-canonic pathway). In the classical signaling pathway, both progesterone and 5α-dihydroprogesterone (5αDHP) bind to intracellular progesterone receptors (PR), which dimerize and translocate to the nucleus, thus interacting with the regulatory progesterone response elements (PRE) in the DNA, which regulates the expression of specific genes. While in the non-classical pathway, there is an activation of G protein-coupled membrane progesterone receptors (mPRs) and progesterone receptor membrane component 1 (PGRMC1), leading to activation of MAPK, protein kinase C (PKC), and PI3K / Akt pathways. 5α-dihydroprogesterone is converted to allopregnanolone. The latter has no affinity for PR but is a positive modulator of type A γ-aminobutyric acid receptors (GABAA) and is also a ligand for mPRs. MBP: myelin basic protein, ∆ᴪm: mitochondrial membrane potential. [ATTACH type="full"]23200[/ATTACH][/B] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progestogen-mediated neuroprotection in central nervous system disorders
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