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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone in Men
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<blockquote data-quote="FunkOdyssey" data-source="post: 269919" data-attributes="member: 44064"><p>I injected a physiologic dose of 1 - 1.5 mg progesterone last night and felt... nothing. Nothing at all. Oura ring showed no effect on any aspect of sleep architecture, duration, HRV, etc either. This in contrast to topical progesterone, which has a strong drug-like sedative effect and felt like taking a benzodiazepine, presumably due to an unnatural degree of conversion into allopregnanolone.</p><p></p><p>Do you guys that inject progesterone do it because you are sold on the idea of keeping every hormone in its normal range or do you realize any concrete benefit from it?</p><p></p><p>If the two options are 1) inject progesterone to reach a normal physiological value with no discernable effect or 2) use topical progesterone to hit yourself over the head with sedation then I'm starting to understand why 99.9% of men on TRT do not bother with this.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 269919, member: 44064"] I injected a physiologic dose of 1 - 1.5 mg progesterone last night and felt... nothing. Nothing at all. Oura ring showed no effect on any aspect of sleep architecture, duration, HRV, etc either. This in contrast to topical progesterone, which has a strong drug-like sedative effect and felt like taking a benzodiazepine, presumably due to an unnatural degree of conversion into allopregnanolone. Do you guys that inject progesterone do it because you are sold on the idea of keeping every hormone in its normal range or do you realize any concrete benefit from it? If the two options are 1) inject progesterone to reach a normal physiological value with no discernable effect or 2) use topical progesterone to hit yourself over the head with sedation then I'm starting to understand why 99.9% of men on TRT do not bother with this. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone in Men
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