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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Progesterone for sleep
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<blockquote data-quote="xqfq" data-source="post: 160320" data-attributes="member: 38167"><p>I don't believe that finasteride "inhibits endogenous progesterone." I can't find any evidence of this and I don't know how it would. I saw there are a couple of "post finasteride" studies, but they are not very good studies for saying whether or not finasteride affects progesterone levels. They just looked at a group of people suffering from "post finasteride" symptoms and measured their progesterone; they were lower than normal. That could be a coincidence and not caused by finasteride.</p><p></p><p>Finasteride is similar to progesterone in structure. But I think if finasteride decreased progesterone it would have been noticed by someone at some point. Maybe not. But I didn't see any evidence of this when I searched - let me know if there's something out there.</p><p></p><p>---</p><p></p><p>I tried progesterone cream, which had a greatly sedative effect. I also tried mega-dosing pregnenolone, 3x a day, which worked to raise my progesterone levels but seemed to have other side effects. I may try something else soon. Right now I am sticking to a very simple protocol of just test-e and hcg to see where I am.</p><p></p><p>I had a bad experience recently where I used 20mg of progesterone cream before bed, then 20mg again in the morning. My heart rate increased to 90 - 100 bpm and I was sweating like crazy. I think with the cream, sometimes less is more.</p><p></p><p>I also think the cream does something different in the body than, say, injectable progesterone. The cream can give supraphysiological progesterone levels in some tissues but not others. It also may increase 5-AR metabolites like allopregnenolone much more than injectable progesterone:</p><p></p><p><a href="https://en.wikipedia.org/wiki/Pharmacokinetics_of_progesterone" target="_blank">Pharmacokinetics of progesterone - Wikipedia</a></p></blockquote><p></p>
[QUOTE="xqfq, post: 160320, member: 38167"] I don't believe that finasteride "inhibits endogenous progesterone." I can't find any evidence of this and I don't know how it would. I saw there are a couple of "post finasteride" studies, but they are not very good studies for saying whether or not finasteride affects progesterone levels. They just looked at a group of people suffering from "post finasteride" symptoms and measured their progesterone; they were lower than normal. That could be a coincidence and not caused by finasteride. Finasteride is similar to progesterone in structure. But I think if finasteride decreased progesterone it would have been noticed by someone at some point. Maybe not. But I didn't see any evidence of this when I searched - let me know if there's something out there. --- I tried progesterone cream, which had a greatly sedative effect. I also tried mega-dosing pregnenolone, 3x a day, which worked to raise my progesterone levels but seemed to have other side effects. I may try something else soon. Right now I am sticking to a very simple protocol of just test-e and hcg to see where I am. I had a bad experience recently where I used 20mg of progesterone cream before bed, then 20mg again in the morning. My heart rate increased to 90 - 100 bpm and I was sweating like crazy. I think with the cream, sometimes less is more. I also think the cream does something different in the body than, say, injectable progesterone. The cream can give supraphysiological progesterone levels in some tissues but not others. It also may increase 5-AR metabolites like allopregnenolone much more than injectable progesterone: [URL='https://en.wikipedia.org/wiki/Pharmacokinetics_of_progesterone']Pharmacokinetics of progesterone - Wikipedia[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Progesterone for sleep
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