ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone Dose for Men
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 211934" data-attributes="member: 38109"><p>Progesterone is characterized as "a known competitor for 5 alpha-reductase"[<a href="https://pubmed.ncbi.nlm.nih.gov/6542470/" target="_blank">R</a>]. This is the only mechanism I've come across for its reduction of 5ar activity.</p><p></p><p>I consider oral delivery to be rather unpredictable: "The metabolism of progesterone is complex, and it may form as many as 35 different unconjugated metabolites when it is ingested orally."[<a href="https://en.wikipedia.org/wiki/Progesterone#Metabolism" target="_blank">R</a>] "Sedation and cognitive and memory impairment with progesterone are attributable to its inhibitory neurosteroid metabolites. These metabolites occur to a greater extent with oral progesterone, and may be minimized by switching to a parenteral route."[<a href="https://en.wikipedia.org/wiki/Progesterone_(medication)#Central_depression" target="_blank">R</a>]</p><p></p><p>I find injected and topical progesterone to be calming, whereas oral pregnenolone and topical DHEA both provoke significant anxiety. "Progesterone, through its neurosteroid active metabolites such as 5α-dihydroprogesterone and allopregnanolone, acts indirectly as a <strong>positive</strong> allosteric modulator of the GABA-A receptor."[<a href="https://en.wikipedia.org/wiki/Progesterone#Biological_activity" target="_blank">R</a>] DHEA, DHEA-S and pregnenolone sulfate are all <strong>negative</strong> allosteric modulators of the GABA-A receptor. It's unclear why I don't have problems with oral DHEA, which I assume is largely converted to DHEA-S, supposedly having a similar negative effect on the GABA-A receptor.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 211934, member: 38109"] Progesterone is characterized as "a known competitor for 5 alpha-reductase"[[URL='https://pubmed.ncbi.nlm.nih.gov/6542470/']R[/URL]]. This is the only mechanism I've come across for its reduction of 5ar activity. I consider oral delivery to be rather unpredictable: "The metabolism of progesterone is complex, and it may form as many as 35 different unconjugated metabolites when it is ingested orally."[[URL='https://en.wikipedia.org/wiki/Progesterone#Metabolism']R[/URL]] "Sedation and cognitive and memory impairment with progesterone are attributable to its inhibitory neurosteroid metabolites. These metabolites occur to a greater extent with oral progesterone, and may be minimized by switching to a parenteral route."[[URL='https://en.wikipedia.org/wiki/Progesterone_(medication)#Central_depression']R[/URL]] I find injected and topical progesterone to be calming, whereas oral pregnenolone and topical DHEA both provoke significant anxiety. "Progesterone, through its neurosteroid active metabolites such as 5α-dihydroprogesterone and allopregnanolone, acts indirectly as a [B]positive[/B] allosteric modulator of the GABA-A receptor."[[URL='https://en.wikipedia.org/wiki/Progesterone#Biological_activity']R[/URL]] DHEA, DHEA-S and pregnenolone sulfate are all [B]negative[/B] allosteric modulators of the GABA-A receptor. It's unclear why I don't have problems with oral DHEA, which I assume is largely converted to DHEA-S, supposedly having a similar negative effect on the GABA-A receptor. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone Dose for Men
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top