My E2 was 41 pg/ml Labcorp sensitive (same range as you) before trying Prog. E2 level after 3 weeks of ~20 mg Prog cream daily was 128 pg/ml. Experienced increased moodiness and softer erections. The only change in my TRT protocol during this period was adding the Prog.
I have always been on the high side with E2. Been on TRT for 8 years, 65 yr old, 6' 1", 220lb, total Test 550 ng/ml, E2 LC/MS Labcorp 58 pg/ml currently with ~5 mg prog EOD. Haven't checked prog blood levels. Have been a type II diabetic for 26 years which is probably why my E2 is always high. Also have BPH for over 10 yrs. I take 62mg Test cypionate SQ twice weekly, .21 mg anastrazole daily, 12.5 mg DHEA daily, ~5 mg Prog cream scrotal EOD, NO HCG. DHEA likely increases E2 as well, but I feel better with a little DHEA on board.
Prog is an aromatase inhibitor, but it is not a strong one like anastrazole, etc.
Adding Prog can increase test and increased test eventually is converted to E2 and/or DHT.
May seem impossible, but it is not. There is often significant variation between individuals which is readily apparent in reading this forum. Also, the literature is not always correct and Nobel prizes have been given to research that ultimately has been proven wrong.
