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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone as Anti-Estrogen
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<blockquote data-quote="Cataceous" data-source="post: 214351" data-attributes="member: 38109"><p>Typically progesterone is considered to be calming. Both it and its metabolite allopregnanolone are positive allosteric modulators of the GABA-A receptor, with effects described as anxiolytic, sedative and anticonvulsant. Your relatively high hCG dose is likely contributing to your progesterone production.</p><p></p><p>Your estradiol does seem low relative to testosterone. Nonetheless, with your TRT dosing being quite high I would start there in looking to reduce imbalances. You're averaging 18 mg per day of testosterone. That's approaching three times what healthy young men make, on average. As a first step I would try reducing to 28 mg EOD TE and also reduce the hCG to 750-1000 IU per week. Dose reductions are often unpleasant, but you need to ride it out and then evaluate how you feel after a few months. It's possible that additional dose reductions would be useful. If you're still having problems after you've fairly evaluated a number of physiological testosterone doses then you might start playing with other variables, including estradiol.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214351, member: 38109"] Typically progesterone is considered to be calming. Both it and its metabolite allopregnanolone are positive allosteric modulators of the GABA-A receptor, with effects described as anxiolytic, sedative and anticonvulsant. Your relatively high hCG dose is likely contributing to your progesterone production. Your estradiol does seem low relative to testosterone. Nonetheless, with your TRT dosing being quite high I would start there in looking to reduce imbalances. You're averaging 18 mg per day of testosterone. That's approaching three times what healthy young men make, on average. As a first step I would try reducing to 28 mg EOD TE and also reduce the hCG to 750-1000 IU per week. Dose reductions are often unpleasant, but you need to ride it out and then evaluate how you feel after a few months. It's possible that additional dose reductions would be useful. If you're still having problems after you've fairly evaluated a number of physiological testosterone doses then you might start playing with other variables, including estradiol. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone as Anti-Estrogen
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