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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone as Anti-Estrogen
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<blockquote data-quote="AndroChishti" data-source="post: 214346" data-attributes="member: 43389"><p>Hi All, this is my second post here and it is going to be a long one so please bear with me. </p><p></p><p>I am amazed at the quality and depth of information available here, and grateful for the advice and help that experienced men on TRT provide here.</p><p></p><p><strong>Bloodwork : (After 3 months on TRT)</strong></p><ul> <li data-xf-list-type="ul"><strong>Total Testosterone</strong> : >1000 ng/dl</li> <li data-xf-list-type="ul"><strong>Free Testosterone</strong>: 30 pg/ml</li> <li data-xf-list-type="ul"><strong>Estradiol</strong>: 50pg/ml</li> <li data-xf-list-type="ul"><strong>DHT</strong>: 1200 pg/ml ref. range: 250 - 850 pg/ml</li> <li data-xf-list-type="ul"><strong>SHBG</strong> : 26 nmol/L</li> <li data-xf-list-type="ul"><strong>Progesterone</strong> : 1.5 ng/mL or 4.77 nmol/L</li> <li data-xf-list-type="ul"><strong>Urine Free Cortisol</strong> : 57 ug/Day </li> <li data-xf-list-type="ul"><strong>Serum Cortisol (Mid-day)</strong>: 22 ug/dl </li> <li data-xf-list-type="ul"><strong>DHEA</strong>: 500 ug/dl</li> <li data-xf-list-type="ul"><strong>TSH</strong>: 1.8 </li> </ul><p></p><p>In this post I would like to discuss some my case in a bit more depth. I have been on TRT for the past 6 months and have never had full symptom resolution on it. Though gains in the gym are great, but I have not so great Acne (bad) , Libido, ED and Anxiety (which I never had prior to TRT). </p><p></p><p>Especially Anxiety, my resting heart rate has increased from 75bpm to 88bpm, I run out of breath very easily easily with clapping jaws and heart palpitations when I lie down to sleep. These symptoms get worse a lot more worse with 0.05mg Arimidex MWF which is already an extremely low dose, and I get all the low E2 symptoms (especially joint pain, palpitations and anorgasmia) even with it being in the 20-25 range.</p><p></p><p>I always thought that the culprit would be SHBG but after seeing bloodwork here, I believe my SHBG is not that low to cause such symptoms.</p><p></p><p>Which brings me to Progesterone, it is known that Progesterone acts as an indirect antagonist to Estradiol. My adrenals are overactive and that is the source of excess progesterone and not the testis (because of HPTA suppression). My progesterone levels are 4 times the normal (as mentioned by Nelson in one of the posts) I need advise if my progesterone is really that high to cause low E2 symptoms? If so should I supplement oral Estradiol Valerate to offset high progesterone?</p><p></p><p>Note : I have pubertal gyno, but on TRT (50mg EOD Test E) and 1500IU HCG MWF, I dont suffer from nipple sensitivity or swelling and I also dont get a lot of water retention or the bloaty look.</p><p></p><p></p><p>Thanks in advance for any advise/help.</p></blockquote><p></p>
[QUOTE="AndroChishti, post: 214346, member: 43389"] Hi All, this is my second post here and it is going to be a long one so please bear with me. I am amazed at the quality and depth of information available here, and grateful for the advice and help that experienced men on TRT provide here. [B]Bloodwork : (After 3 months on TRT)[/B] [LIST] [*][B]Total Testosterone[/B] : >1000 ng/dl [*][B]Free Testosterone[/B]: 30 pg/ml [*][B]Estradiol[/B]: 50pg/ml [*][B]DHT[/B]: 1200 pg/ml ref. range: 250 - 850 pg/ml [*][B]SHBG[/B] : 26 nmol/L [*][B]Progesterone[/B] : 1.5 ng/mL or 4.77 nmol/L [*][B]Urine Free Cortisol[/B] : 57 ug/Day [*][B]Serum Cortisol (Mid-day)[/B]: 22 ug/dl [*][B]DHEA[/B]: 500 ug/dl [*][B]TSH[/B]: 1.8 [/LIST] In this post I would like to discuss some my case in a bit more depth. I have been on TRT for the past 6 months and have never had full symptom resolution on it. Though gains in the gym are great, but I have not so great Acne (bad) , Libido, ED and Anxiety (which I never had prior to TRT). Especially Anxiety, my resting heart rate has increased from 75bpm to 88bpm, I run out of breath very easily easily with clapping jaws and heart palpitations when I lie down to sleep. These symptoms get worse a lot more worse with 0.05mg Arimidex MWF which is already an extremely low dose, and I get all the low E2 symptoms (especially joint pain, palpitations and anorgasmia) even with it being in the 20-25 range. I always thought that the culprit would be SHBG but after seeing bloodwork here, I believe my SHBG is not that low to cause such symptoms. Which brings me to Progesterone, it is known that Progesterone acts as an indirect antagonist to Estradiol. My adrenals are overactive and that is the source of excess progesterone and not the testis (because of HPTA suppression). My progesterone levels are 4 times the normal (as mentioned by Nelson in one of the posts) I need advise if my progesterone is really that high to cause low E2 symptoms? If so should I supplement oral Estradiol Valerate to offset high progesterone? Note : I have pubertal gyno, but on TRT (50mg EOD Test E) and 1500IU HCG MWF, I dont suffer from nipple sensitivity or swelling and I also dont get a lot of water retention or the bloaty look. Thanks in advance for any advise/help. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Progesterone as Anti-Estrogen
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