Yes it's faster than conventional transdermal. But still not as fast as Natesto, which could compromise the hpta normal fonction

I found this study:

METABOLISM OF DMSO

Regardless of the route of administration of DMSO, a remarkable amount of radioactive DMSO is found in the plasma after only 30 minutes. Cutaneous administration of DMSO generally results in lower serum levels

than when DMSO is administered per os or intravenously.7 Maximal blood concentrations of DMSO applied cutaneously are reached in 2 hours.

An oral dose of 1g/kg-body weight results in peak plasma concentrations in 4 - 6 hours, and detectable levels persisted for 400 hours. DMSO administered intravenously at the same dosage achieves higher plasma levels and is rapidly distributed throughout all tissues.

DMSO is metabolized in animals and man to form dimethyl sulfide (DMS) and dimethyl sulfone (DMS02 ). DMSO and DMS02 arepresent in all examined tissues including both hard (i. e. lens and bone) and soft tissues. 3 Unaltered DMSO is by far the most prevalent in tissues, blood, feces' and urine, with DMS02 also present but in much smaller concentrations. A small percentage of the original dose of DMSO is reduced to DMS and exhaled.

It appears that the primary route of excretion of DMSO is through the urine. 8 One and one-half to two hours after cutaneous administration of DMSO, the highest concentration is found in the kidneys, indicating that

the kidney is the organ of excretion. In dogs, studies indicate that approximately 50% of a total dose of DMSO-35S is collected in urine after 36 hours whether given by oral or intravenous administration. 8 When DMSO-35S is applied cutaneously, only 12 - 25 % of the total dose is found in the urine collected over a

24 hour period. Only a small fraction of an original dose of DMSO is excreted in the feces, regardless of the route of administration. The biliary system also appears to play a role in the excretion of DMSO. In rats administered DMSO intravenously, 8% of the total dose is recovered in a 24 hour period. This suggests that a large portion of the DMSO dose is reabsorbed in the enterohepatic circulation.

The odoriferous breath associated with administration of DMSO led researchers to investigate the possibility of pulmonary excretion. It was found that a small amount of DMSO is reduced to DMS and exhaled in the breath. Approximately 3-6% of a total DMSO dose is exhaled in the breath, regardless of the route of administration.