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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Primary hypogonadism induced by steroids
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<blockquote data-quote="DesperatedGuy" data-source="post: 220218" data-attributes="member: 43705"><p>"False, unless proven otherwise. The testosterone absorbs via the thin skin and enters systemic circulation."</p><p></p><p>Honestly maybe i am wrong but it feels logical to me. DHT gel is used for gynecomastia and it worked for me. Same thing for transdermal tamoxifen used in breast cancer, it works applied on the breast while reducing systemic levels and sides. it can definitely act locally for a certain period of time. This is the same thing for NSAID. For exemple, Diclofenac gel is used to treat joint inflammation while reducing systemic exposure and sides compared with oral diclofenac</p><p></p><p>I am not contradicting. I am talking about suppression of LH and FSH levels. Spermatogenesis can happens without LH and FSH with artificial testosterone presence. I read a study where they suppressed FSH and LH in rats but injected testosterone directly in the testis and it induced spermatogenesis (i tried to find the study but i dont remember where i read it). So in theory you can have ITT/spermatogenesis while being totally shutdown (no LH and FSH) if you use this method. But of course FSH is important for optimal spermatogenesis too.</p><p></p><p>Suppression doesn't only happens in the pituitary. It also can happens via Leydig cells feedback when they detect presence of androgens.</p></blockquote><p></p>
[QUOTE="DesperatedGuy, post: 220218, member: 43705"] "False, unless proven otherwise. The testosterone absorbs via the thin skin and enters systemic circulation." Honestly maybe i am wrong but it feels logical to me. DHT gel is used for gynecomastia and it worked for me. Same thing for transdermal tamoxifen used in breast cancer, it works applied on the breast while reducing systemic levels and sides. it can definitely act locally for a certain period of time. This is the same thing for NSAID. For exemple, Diclofenac gel is used to treat joint inflammation while reducing systemic exposure and sides compared with oral diclofenac I am not contradicting. I am talking about suppression of LH and FSH levels. Spermatogenesis can happens without LH and FSH with artificial testosterone presence. I read a study where they suppressed FSH and LH in rats but injected testosterone directly in the testis and it induced spermatogenesis (i tried to find the study but i dont remember where i read it). So in theory you can have ITT/spermatogenesis while being totally shutdown (no LH and FSH) if you use this method. But of course FSH is important for optimal spermatogenesis too. Suppression doesn't only happens in the pituitary. It also can happens via Leydig cells feedback when they detect presence of androgens. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Primary hypogonadism induced by steroids
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