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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Primary hypogonadism induced by steroids
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<blockquote data-quote="Cataceous" data-source="post: 220217" data-attributes="member: 38109"><p>Yes, as long as the dose isn't too high. Your serum testosterone should end up near where it would be naturally if the testicles were ok. You will need to be patient with the process—start low with the dose and increase slowly, monitoring LH.</p><p></p><p>I doubt scrotal cream is more suppressive than other forms of TRT. The degree of suppression should mainly be a function of the levels of circulating estrogens and androgens. Excess DHT caused by scrotal application cuts both ways: Being a strong androgen means it's possible that DHT is more suppressive than testosterone at the hypothalamus. However, DHT is also a potent anti-estrogen, which can reduce negative feedback from estradiol at both the hypothalamus and pituitary. The situation is further complicated by the interaction with the SHBG carrier protein. Higher DHT can increase the amount of free estradiol and free testosterone.</p><p></p><p>I have reservations about topical TRT in general because DHT frequently ends up higher than is physiological. Maybe it's ok, but it's still possible it will lead to other problems.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220217, member: 38109"] Yes, as long as the dose isn't too high. Your serum testosterone should end up near where it would be naturally if the testicles were ok. You will need to be patient with the process—start low with the dose and increase slowly, monitoring LH. I doubt scrotal cream is more suppressive than other forms of TRT. The degree of suppression should mainly be a function of the levels of circulating estrogens and androgens. Excess DHT caused by scrotal application cuts both ways: Being a strong androgen means it's possible that DHT is more suppressive than testosterone at the hypothalamus. However, DHT is also a potent anti-estrogen, which can reduce negative feedback from estradiol at both the hypothalamus and pituitary. The situation is further complicated by the interaction with the SHBG carrier protein. Higher DHT can increase the amount of free estradiol and free testosterone. I have reservations about topical TRT in general because DHT frequently ends up higher than is physiological. Maybe it's ok, but it's still possible it will lead to other problems. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Primary hypogonadism induced by steroids
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