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If I have natural DHEA-S levels at the top end of the range, sometimes slightly over, is it physiologically impossible for my pregnenolone levels to be low? DHEA can only be made from pregnenolone, correct? So in order for my DHEA to be high, I must have good levels of pregnenolone, right? What do you guys think. FYI, every time I’ve had pregnenolone tested with Quest, it’s comes back <5. So extremely low, according to them. But not sure how reliable the pregnenolone test is, I’ve heard it’s not the best. I ask because I’m trialing out a tiny dose of pregnenolone cream from Empower, and I think it might be giving me a spaced out feeling. I have brain fog, so not sure if it’s just the brain fog, or if I’m a little more spacey due to the pregnenolone.

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[QUOTE="Gman86, post: 138270, member: 15043"] If I have natural DHEA-S levels at the top end of the range, sometimes slightly over, is it physiologically impossible for my pregnenolone levels to be low? DHEA can only be made from pregnenolone, correct? So in order for my DHEA to be high, I must have good levels of pregnenolone, right? What do you guys think. FYI, every time I’ve had pregnenolone tested with Quest, it’s comes back <5. So extremely low, according to them. But not sure how reliable the pregnenolone test is, I’ve heard it’s not the best. I ask because I’m trialing out a tiny dose of pregnenolone cream from Empower, and I think it might be giving me a spaced out feeling. I have brain fog, so not sure if it’s just the brain fog, or if I’m a little more spacey due to the pregnenolone. [ATTACH=full]6812[/ATTACH] [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038