I'm currently doing 50mg cap SR and 50mg Cream, all in the am. Blood level is at 60 ng/dl, I find the cream raise blood level just slightly. When I'm on 100mg cap only, blood level always come back about 100 ng/dl, and that is where I believe I obtain most of the benefits from it, especially with the IR I believe. If I go above that, I do think I see an elevation in heart rate due to anxiety in my case.
a year or two ago, I also thought the Preg cream would give me an increased heart rate, but since stopping the Coq10 supplement, I have never experienced it again.