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General Health & Fitness
Pain Management Research
Pregnenolone Decreases Veterans' Chronic Back Pain More than Placebo
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<blockquote data-quote="Nelson Vergel" data-source="post: 214183" data-attributes="member: 3"><p><strong>Normalization of serum pregnenolone is associated</strong></p><p><strong>with enhanced pain control</strong></p><p>F. Tennant; Veract Palliative Care Medical Clinic, West Covina, CA</p><p></p><p>Pregnenolone is the metabolic precursor of multiple adrenal and sex</p><p>hormones, and it also is a neurosteroid involved in regulating neuronal</p><p>plasticity and function. Consequently adequate body fluid concentrations</p><p>may be essential for long term pain control and neurologic function.</p><p>Subjects were (18) severe, persistent pain patients from a variety of</p><p>causes who had inadequate pain control with a morphine equivalency</p><p>of 50-100mg/d. They also had sub-normal serum pregnenolone concentrations</p><p>below 20ng/dl. Patients had their daily opioid dosage increased</p><p>to a morphine equivalence of 400-1000 mg/d. After 90 days a repeat</p><p>pregnenolone serum concentration was determined, and patients were</p><p>reassessed for pain score, sleep, endurance, and well-being. Six subjects</p><p>maintained at the higher morphine equivalence dosage decompensated</p><p>a few months into treatment and developed severe pain and a house or</p><p>bed-bound state. All demonstrated sub-normal serum pregnenolone</p><p>concentrations, so pregnenolone supplements ranging from 50 to 200</p><p>mg/d were administered. Serum pregnenolone concentrations raised to</p><p>normal in 14 of the 18 subjects and mean serum concentration raised</p><p>from 13.6 3.0 to 50.1 2.7 (P.001). All patients reported some</p><p>improvement in pain relief, endurance, sleep, and well-being. The six</p><p>decompensated patients restablished following pregnenolone administration</p><p>and a return to normal serum pregnenolone concentration. Considering</p><p>the essential importance of pregnenolone as a precursor hormone</p><p>and neurosteroid, pregnenolone should be studied as a biologic</p><p>marker for pain control and as a therapeutic adjunct.</p><p>(</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 214183, member: 3"] [B]Normalization of serum pregnenolone is associated with enhanced pain control[/B] F. Tennant; Veract Palliative Care Medical Clinic, West Covina, CA Pregnenolone is the metabolic precursor of multiple adrenal and sex hormones, and it also is a neurosteroid involved in regulating neuronal plasticity and function. Consequently adequate body fluid concentrations may be essential for long term pain control and neurologic function. Subjects were (18) severe, persistent pain patients from a variety of causes who had inadequate pain control with a morphine equivalency of 50-100mg/d. They also had sub-normal serum pregnenolone concentrations below 20ng/dl. Patients had their daily opioid dosage increased to a morphine equivalence of 400-1000 mg/d. After 90 days a repeat pregnenolone serum concentration was determined, and patients were reassessed for pain score, sleep, endurance, and well-being. Six subjects maintained at the higher morphine equivalence dosage decompensated a few months into treatment and developed severe pain and a house or bed-bound state. All demonstrated sub-normal serum pregnenolone concentrations, so pregnenolone supplements ranging from 50 to 200 mg/d were administered. Serum pregnenolone concentrations raised to normal in 14 of the 18 subjects and mean serum concentration raised from 13.6 3.0 to 50.1 2.7 (P.001). All patients reported some improvement in pain relief, endurance, sleep, and well-being. The six decompensated patients restablished following pregnenolone administration and a return to normal serum pregnenolone concentration. Considering the essential importance of pregnenolone as a precursor hormone and neurosteroid, pregnenolone should be studied as a biologic marker for pain control and as a therapeutic adjunct. ( [/QUOTE]
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General Health & Fitness
Pain Management Research
Pregnenolone Decreases Veterans' Chronic Back Pain More than Placebo
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