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When you start TRT it takes 6 weeks for testosterone blood levels to reach a stable state and it may take longer to notice maximum benefits as gene expression takes place and tissue is repaired, of course if you're just starting TRT the time course to maximum benefits in more than 1 year.


A lot of guys expect immediate results are are disappointed and some even quit TRT thinking it doesn't work for them. The first year you will be making adjustments to your TRT protocol to get dialed in, this dialing process will halt or slow if you're working with an inexperienced doctor.


SHBG allows a protocol to be designed, without it the process of dialing in is already slowed.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188848/


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