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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Pre-Defy consult lab work
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<blockquote data-quote="Cataceous" data-source="post: 247305" data-attributes="member: 38109"><p>I'm always in favor of exploring a range of physiological testosterone doses before heading higher. Better late than never. The problem is that dose reductions are sometimes unpleasant for a prolonged period. It's still worth it, but it's more mentally challenging than following a low-and-slow dosing strategy from the beginning. If the testosterone doses are reasonably spread out then the physiological range is covered by roughly 40-110 mg testosterone cypionate per week. This makes 100 mg per week a pretty high-end dose, contrary to popular perception. Taking testosterone cypionate in one dose per week typically causes large swings in serum levels. If you measured that 592 ng/dL at trough then you could have a peak at around 1,200-1,500 ng/dL. Such variation is not natural and probably leads to poor results for more than a few men on TRT. I list some anecdotes <a href="https://www.excelmale.com/forum/threads/answering-some-questions-new-to-forum-much-appreciated.26955/post-245316" target="_blank">here</a> where guys describe getting better results after pushing through with dose reductions. </p><p></p><p>I have a lot of good things to say about Defy Medical, and I'm a patient as well. But I do think they tend to prescribe more testosterone than necessary. It's good to go in knowing what's physiological so you can push back against higher doses.</p><p></p><p></p><p>No, that's the same misconception. Consider this: if you inject 10 mg of testosterone cypionate per day then you're getting 7 mg of testosterone daily. At steady state you must metabolize 7 mg of testosterone daily, regardless of what your SHBG is doing. Low SHBG does not lead to more free testosterone and enhanced metabolism.</p><p></p><p>That said, low SHBG is associated with some bad things, and it may still have some negative effects on androgen signaling, independent of free testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 247305, member: 38109"] I'm always in favor of exploring a range of physiological testosterone doses before heading higher. Better late than never. The problem is that dose reductions are sometimes unpleasant for a prolonged period. It's still worth it, but it's more mentally challenging than following a low-and-slow dosing strategy from the beginning. If the testosterone doses are reasonably spread out then the physiological range is covered by roughly 40-110 mg testosterone cypionate per week. This makes 100 mg per week a pretty high-end dose, contrary to popular perception. Taking testosterone cypionate in one dose per week typically causes large swings in serum levels. If you measured that 592 ng/dL at trough then you could have a peak at around 1,200-1,500 ng/dL. Such variation is not natural and probably leads to poor results for more than a few men on TRT. I list some anecdotes [URL='https://www.excelmale.com/forum/threads/answering-some-questions-new-to-forum-much-appreciated.26955/post-245316']here[/URL] where guys describe getting better results after pushing through with dose reductions. I have a lot of good things to say about Defy Medical, and I'm a patient as well. But I do think they tend to prescribe more testosterone than necessary. It's good to go in knowing what's physiological so you can push back against higher doses. No, that's the same misconception. Consider this: if you inject 10 mg of testosterone cypionate per day then you're getting 7 mg of testosterone daily. At steady state you must metabolize 7 mg of testosterone daily, regardless of what your SHBG is doing. Low SHBG does not lead to more free testosterone and enhanced metabolism. That said, low SHBG is associated with some bad things, and it may still have some negative effects on androgen signaling, independent of free testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Pre-Defy consult lab work
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