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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Pre-Defy consult lab work
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<blockquote data-quote="Cataceous" data-source="post: 247292" data-attributes="member: 38109"><p>No, that older line of thought is being challenged. Newer thinking is that SHBG has little effect on free testosterone in normal situations. Instead, free testosterone is driven proportionally by the testosterone production rate or dose rate, at least at steady state. Fluctuations in SHBG are more directly reflected in total testosterone. In your case total testosterone of 1,237 ng/dL is on the low side considering the extremely high free testosterone. This is the result of having low SHBG. SHBG might be thought of as a storage reservoir for testosterone. A small reservoir means less testosterone can be stored at one time, thus total testosterone is lower. Free testosterone is akin to the flow rates into and out of the reservoir. The rates are independent of the size of the reservoir, except transiently during size changes.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 247292, member: 38109"] No, that older line of thought is being challenged. Newer thinking is that SHBG has little effect on free testosterone in normal situations. Instead, free testosterone is driven proportionally by the testosterone production rate or dose rate, at least at steady state. Fluctuations in SHBG are more directly reflected in total testosterone. In your case total testosterone of 1,237 ng/dL is on the low side considering the extremely high free testosterone. This is the result of having low SHBG. SHBG might be thought of as a storage reservoir for testosterone. A small reservoir means less testosterone can be stored at one time, thus total testosterone is lower. Free testosterone is akin to the flow rates into and out of the reservoir. The rates are independent of the size of the reservoir, except transiently during size changes. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Pre-Defy consult lab work
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