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General Health & Fitness
Nutrition and Supplements
Poll: Have You Used Injectable Amino Acids?
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 74378" data-attributes="member: 12687"><p>Agree with most of your post, but you are confusing the IGF-1 lab test with the GH lab test. </p><p></p><p>IGF-1 has a much longer half life after it is produced by the liver (12-15 hours), whereas GH only has a half life of <20 min when secreted by the pituitary. The liver then produces IGF-1 in response to the pituitary's release of GH, which is why we use IGF-1 as a surrogate for measurement of GH levels (an adequate but not perfect surrogate, especially in cases of liver dysfunction). </p><p></p><p>Correct that most GH is secreted at night (and only in brief pulses), so checking a GH test (except for a 3 specimen GH stimulation where you take sermorelin as part of the test) is useless. The IGF-1, however, will be elevated during the day for a blood test if the sermorelin is stimulating increased GH production at night.</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 74378, member: 12687"] Agree with most of your post, but you are confusing the IGF-1 lab test with the GH lab test. IGF-1 has a much longer half life after it is produced by the liver (12-15 hours), whereas GH only has a half life of <20 min when secreted by the pituitary. The liver then produces IGF-1 in response to the pituitary's release of GH, which is why we use IGF-1 as a surrogate for measurement of GH levels (an adequate but not perfect surrogate, especially in cases of liver dysfunction). Correct that most GH is secreted at night (and only in brief pulses), so checking a GH test (except for a 3 specimen GH stimulation where you take sermorelin as part of the test) is useless. The IGF-1, however, will be elevated during the day for a blood test if the sermorelin is stimulating increased GH production at night. [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
Poll: Have You Used Injectable Amino Acids?
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