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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 234563" data-attributes="member: 38109"><p>I did try again to forgo enclomiphene while lowering the TRT dose. This time there was not the testicular discomfort, but as I recall, gonadotropin production was basically lost and subjective results deteriorated.</p><p></p><p>Thus I'm not particularly optimistic about GnRH alone as a restart tool. It depends on how sensitive your pituitary is to negative feedback from estrogen. It should work when the exogenous testosterone is low enough—but if that puts you in hypogonadal territory then it's less helpful. I'd agree there's probably not much risk in trying it.</p><p></p><p>I hesitate to predict what would happen if GnRH is continued when TRT is completely stopped. I suppose it could be helpful in stimulating the pituitary in the interval before the hypothalamus fully reactivates. As I recall, the research involving administration of GnRH to normal individuals didn't reveal anything very bad happening, at least in the short run.</p><p></p><p>More as a thought experiment, I've proposed a full restart while on TRT. This includes taking a SERM, kisspeptin, GnRH and hCG. The idea is that you may be able to regain some functionality in each part of the HPTA before ending TRT. There is uncertainly about how long it would take for each element to restart, so it would be difficult to stagger the different drugs in an optimal manner. But presumably you'd still get results in time if you started everything simultaneously.</p><p></p><p></p><p>Do a search for our discussion of the Royal Medical Center results. They have posted lab work from quite a few patients showing that isolated and fairly large doses of GnRH produce robust LH in a lot of men on TRT. The protocol is something like 50-100 mcg twice a week. It's interesting work, but I haven't seen feedback on whether the subjective results make it worthwhile. I'm skeptical that it is comparable to using hCG. The assumption is that the guys only see a single LH pulse shortly after each GnRH injection. I don't think they stated how long guys needed to be on the protocol to see significant LH. A possible implication is that supraphysiological doses can overcome fairly significant negative feedback from estrogen. However, many of these guys were on AIs, so it's not entirely clear what's going on.</p><p>[URL unfurl="true"]https://www.royalmedicalcenters.com/gonadorelin/[/URL]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 234563, member: 38109"] I did try again to forgo enclomiphene while lowering the TRT dose. This time there was not the testicular discomfort, but as I recall, gonadotropin production was basically lost and subjective results deteriorated. Thus I'm not particularly optimistic about GnRH alone as a restart tool. It depends on how sensitive your pituitary is to negative feedback from estrogen. It should work when the exogenous testosterone is low enough—but if that puts you in hypogonadal territory then it's less helpful. I'd agree there's probably not much risk in trying it. I hesitate to predict what would happen if GnRH is continued when TRT is completely stopped. I suppose it could be helpful in stimulating the pituitary in the interval before the hypothalamus fully reactivates. As I recall, the research involving administration of GnRH to normal individuals didn't reveal anything very bad happening, at least in the short run. More as a thought experiment, I've proposed a full restart while on TRT. This includes taking a SERM, kisspeptin, GnRH and hCG. The idea is that you may be able to regain some functionality in each part of the HPTA before ending TRT. There is uncertainly about how long it would take for each element to restart, so it would be difficult to stagger the different drugs in an optimal manner. But presumably you'd still get results in time if you started everything simultaneously. Do a search for our discussion of the Royal Medical Center results. They have posted lab work from quite a few patients showing that isolated and fairly large doses of GnRH produce robust LH in a lot of men on TRT. The protocol is something like 50-100 mcg twice a week. It's interesting work, but I haven't seen feedback on whether the subjective results make it worthwhile. I'm skeptical that it is comparable to using hCG. The assumption is that the guys only see a single LH pulse shortly after each GnRH injection. I don't think they stated how long guys needed to be on the protocol to see significant LH. A possible implication is that supraphysiological doses can overcome fairly significant negative feedback from estrogen. However, many of these guys were on AIs, so it's not entirely clear what's going on. [URL unfurl="true"]https://www.royalmedicalcenters.com/gonadorelin/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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