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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 233955" data-attributes="member: 38109"><p>While I haven't definitively ruled this out, I would bet against it. There are a few anecdotal reports of TRT + enclomiphene yielding HPTA activity, but these are outweighed by reported failures and Dr. Saya's clinical experience. Even on the lower TRT dose my nominal daily peak TT is about 600 ng/dL and the trough is upper 300s. This is likely too much testosterone for too long to activate a hypothalamus that already has an unnaturally low set point.</p><p></p><p>Having tried going without enclomiphene more than once I can say that for me the results are degraded without it. This is unusual given the conventional wisdom you mention. I've speculated that my relatively high rate of aromatization is a contributing factor. If you start out with your E2/T ratio in the low-to-mid range of 0.3-0.4% then perhaps enclomiphene reduces estrogenic activity by too much in some locations. In contrast, I don't often see E2/T below 0.5%, and my average over the last couple years has been over 0.7%.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 233955, member: 38109"] While I haven't definitively ruled this out, I would bet against it. There are a few anecdotal reports of TRT + enclomiphene yielding HPTA activity, but these are outweighed by reported failures and Dr. Saya's clinical experience. Even on the lower TRT dose my nominal daily peak TT is about 600 ng/dL and the trough is upper 300s. This is likely too much testosterone for too long to activate a hypothalamus that already has an unnaturally low set point. Having tried going without enclomiphene more than once I can say that for me the results are degraded without it. This is unusual given the conventional wisdom you mention. I've speculated that my relatively high rate of aromatization is a contributing factor. If you start out with your E2/T ratio in the low-to-mid range of 0.3-0.4% then perhaps enclomiphene reduces estrogenic activity by too much in some locations. In contrast, I don't often see E2/T below 0.5%, and my average over the last couple years has been over 0.7%. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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