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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 228895" data-attributes="member: 38109"><p>Yes. The indirect evidence suggests my serum testosterone peaks with propionate and propionate blends are around three hours post-injection, which is when this measurement was made.</p><p></p><p>According to Wikipedia, "The largest amounts of testosterone (>95%) are produced by the testes in men,<a href="https://en.wikipedia.org/wiki/Testosterone#cite_note-Mooradian_1987-4" target="_blank">[4]</a> while the adrenal glands account for most of the remainder." If this figure is accurate then non-testicular production could get lost in the noise.</p><p></p><p>I'll split some hairs too: It's a tough habit to break, but we need to get away from linking total testosterone to the production rate. Total testosterone is also a reflection of how much SHBG one has. Instead we should use free testosterone, which is likely proportional to production or endogenous dosing. Therefore we'd observe that my Vermeulen free testosterone was 15.5 ng/dL, which is right about at the average for healthy young men. Now you can ask, how I can have that level with 4.4 mg of exogenous testosterone per day when the average natural production rate is 6-7 mg? My first observation is that 4.4 mg is still going to be within a couple standard deviations of average natural production, so it's not so unusual. My second observation is that the metabolic clearance rate drops with age, meaning I can expect more bang for the buck.</p><p></p><p>I think the vast majority of guys would be covered by 4-8 mg per day if it can be dosed to imitate a diurnal rhythm.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 228895, member: 38109"] Yes. The indirect evidence suggests my serum testosterone peaks with propionate and propionate blends are around three hours post-injection, which is when this measurement was made. According to Wikipedia, "The largest amounts of testosterone (>95%) are produced by the testes in men,[URL='https://en.wikipedia.org/wiki/Testosterone#cite_note-Mooradian_1987-4'][4][/URL] while the adrenal glands account for most of the remainder." If this figure is accurate then non-testicular production could get lost in the noise. I'll split some hairs too: It's a tough habit to break, but we need to get away from linking total testosterone to the production rate. Total testosterone is also a reflection of how much SHBG one has. Instead we should use free testosterone, which is likely proportional to production or endogenous dosing. Therefore we'd observe that my Vermeulen free testosterone was 15.5 ng/dL, which is right about at the average for healthy young men. Now you can ask, how I can have that level with 4.4 mg of exogenous testosterone per day when the average natural production rate is 6-7 mg? My first observation is that 4.4 mg is still going to be within a couple standard deviations of average natural production, so it's not so unusual. My second observation is that the metabolic clearance rate drops with age, meaning I can expect more bang for the buck. I think the vast majority of guys would be covered by 4-8 mg per day if it can be dosed to imitate a diurnal rhythm. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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