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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 207097" data-attributes="member: 38109"><p>Clomid can be thought of as enclomiphene plus estrogen (zuclomiphene). The enclomiphene is strong enough at the hypothalamus and pituitary to overcome both the endogenous and exogenous estrogens. So Clomid can help with the HPTA activation described in this thread, but with a higher risk of side effects than enclomiphene alone. I'd expect somebody who naturally has higher estradiol relative to testosterone would be at greater risk of side effects than someone who has lower estradiol.</p><p></p><p>On the flip side, somebody who naturally has lower estradiol might do worse with enclomiphene alone, though there's no guarantee that Clomid would compensate for excessive antagonism of estrogen receptors by the enclomiphene component. I mention this because one individual tried this protocol and successfully restarted his pituitary, but his subjective results were poor, and we speculate that the enclomiphene may be to blame. </p><p></p><p>Clomid is a little more than half enclomiphene, so to get the same dose of enclomiphene you would use about twice as much Clomid. However, I wouldn't take more than 25 mg per day, and I would start lower, with 12.5 mg EOD or daily.</p><p></p><p>A significant problem with Clomid is that the zuclomiphene component has a very long half-life, on the order of weeks. This means the build-up of zuclomiphene may take months, and the onset of side effects can be delayed. When Clomid is discontinued it takes a long time for the zuclomiphene to clear, which implies that side effects can linger.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 207097, member: 38109"] Clomid can be thought of as enclomiphene plus estrogen (zuclomiphene). The enclomiphene is strong enough at the hypothalamus and pituitary to overcome both the endogenous and exogenous estrogens. So Clomid can help with the HPTA activation described in this thread, but with a higher risk of side effects than enclomiphene alone. I'd expect somebody who naturally has higher estradiol relative to testosterone would be at greater risk of side effects than someone who has lower estradiol. On the flip side, somebody who naturally has lower estradiol might do worse with enclomiphene alone, though there's no guarantee that Clomid would compensate for excessive antagonism of estrogen receptors by the enclomiphene component. I mention this because one individual tried this protocol and successfully restarted his pituitary, but his subjective results were poor, and we speculate that the enclomiphene may be to blame. Clomid is a little more than half enclomiphene, so to get the same dose of enclomiphene you would use about twice as much Clomid. However, I wouldn't take more than 25 mg per day, and I would start lower, with 12.5 mg EOD or daily. A significant problem with Clomid is that the zuclomiphene component has a very long half-life, on the order of weeks. This means the build-up of zuclomiphene may take months, and the onset of side effects can be delayed. When Clomid is discontinued it takes a long time for the zuclomiphene to clear, which implies that side effects can linger. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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