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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 191712" data-attributes="member: 38109"><p>I haven't tried less frequent dosing of GnRH. I'll speculate that a single daily dose could provide a little benefit through its stimulation of various receptors that are otherwise deprived while we're on TRT. However, I doubt this frequency is enough to sustain LH production, though I'd like to be wrong about this. The treatment would be a lot more accessible if it worked without multiple daily doses.</p><p></p><p>LH is indeed pulsed throughout the day, as in the data below. The half-life of LH is less than an hour, while the half-life of hCG is more like 36 hours. Thus I've speculated about why hCG is problematic: Suppose the peak level of LH is what's most important for various functions. Natural men have these narrows peaks and lots of time at lower baseline levels. Compared to LH levels, hCG levels will seem to be almost constant because they fall so slowly. Matching normal LH peaks with hCG means having relatively high levels of hCG all the time. I suspect this contributes to excessive aromatization and other problems that are associated with hCG.</p><p>[ATTACH=full]11920[/ATTACH]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 191712, member: 38109"] I haven't tried less frequent dosing of GnRH. I'll speculate that a single daily dose could provide a little benefit through its stimulation of various receptors that are otherwise deprived while we're on TRT. However, I doubt this frequency is enough to sustain LH production, though I'd like to be wrong about this. The treatment would be a lot more accessible if it worked without multiple daily doses. LH is indeed pulsed throughout the day, as in the data below. The half-life of LH is less than an hour, while the half-life of hCG is more like 36 hours. Thus I've speculated about why hCG is problematic: Suppose the peak level of LH is what's most important for various functions. Natural men have these narrows peaks and lots of time at lower baseline levels. Compared to LH levels, hCG levels will seem to be almost constant because they fall so slowly. Matching normal LH peaks with hCG means having relatively high levels of hCG all the time. I suspect this contributes to excessive aromatization and other problems that are associated with hCG. [ATTACH type="full" height="500px"]11920[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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