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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 191614" data-attributes="member: 38109"><p>One thing that remains unclear is the importance of enclomiphene in this protocol. To explore this the enclomiphene was discontinued for four weeks. Simultaneously the TRT dose was reduced to the lowest level yet: 2.8 mg testosterone enanthate and 2.1 mg testosterone propionate daily. This is equivalent to taking a mere 38 mg testosterone cypionate per week. The 3.8 mg pure testosterone per day is even on the low side for natural men, who are said to make 3-9 mg per day. Quantitatively, LH and FSH both dropped about 30% by the end of the trial from their previous levels around 2 mIU/mL. Peak total testosterone was 525 ng/dL, somewhat lower than the predicted 600. Peak estradiol was 25 pg/mL, right at the predicted level. The subjective results during this period were generally acceptable, with one significant exception. Libido, sexual function, drive, etc. all stayed reasonable, though with perhaps more variability than previously observed. Unexpectedly, the reason the trial was halted was due to the virtually unrelenting testicular discomfort. While testicular discomfort is not unusual during periods of increasing or decreasing gonadotropins, the greater intensity and fairly continuous nature were such that thoughts of waiting it out were discarded. This is unfortunate from a scientific standpoint, as it would have been useful to see if the gonadotropins continued to decline in the absence of the SERM. Alternatively, given the very low TRT dose, perhaps further reductions would have been minimal.</p><p></p><p>It's unclear why this particular transition would be especially bothersome to the testicles compared to something like starting TRT from scratch. In any case, resumption of 12.5 mg enclomiphene EOD was sufficient to rapidly resolve the issue. The TRT dose was bumped up slightly to 3.2 mg testosterone enanthate and 2.4 mg testosterone propionate daily. Although equivalent to taking only 44 mg testosterone cypionate per week, it's predicted to put daily peak serum testosterone close to 700 ng/dL.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 191614, member: 38109"] One thing that remains unclear is the importance of enclomiphene in this protocol. To explore this the enclomiphene was discontinued for four weeks. Simultaneously the TRT dose was reduced to the lowest level yet: 2.8 mg testosterone enanthate and 2.1 mg testosterone propionate daily. This is equivalent to taking a mere 38 mg testosterone cypionate per week. The 3.8 mg pure testosterone per day is even on the low side for natural men, who are said to make 3-9 mg per day. Quantitatively, LH and FSH both dropped about 30% by the end of the trial from their previous levels around 2 mIU/mL. Peak total testosterone was 525 ng/dL, somewhat lower than the predicted 600. Peak estradiol was 25 pg/mL, right at the predicted level. The subjective results during this period were generally acceptable, with one significant exception. Libido, sexual function, drive, etc. all stayed reasonable, though with perhaps more variability than previously observed. Unexpectedly, the reason the trial was halted was due to the virtually unrelenting testicular discomfort. While testicular discomfort is not unusual during periods of increasing or decreasing gonadotropins, the greater intensity and fairly continuous nature were such that thoughts of waiting it out were discarded. This is unfortunate from a scientific standpoint, as it would have been useful to see if the gonadotropins continued to decline in the absence of the SERM. Alternatively, given the very low TRT dose, perhaps further reductions would have been minimal. It's unclear why this particular transition would be especially bothersome to the testicles compared to something like starting TRT from scratch. In any case, resumption of 12.5 mg enclomiphene EOD was sufficient to rapidly resolve the issue. The TRT dose was bumped up slightly to 3.2 mg testosterone enanthate and 2.4 mg testosterone propionate daily. Although equivalent to taking only 44 mg testosterone cypionate per week, it's predicted to put daily peak serum testosterone close to 700 ng/dL. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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