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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 180159" data-attributes="member: 38109"><p>It's now safer to call this phase of the experiment a success: After one month without hCG there's been no loss of testicular volume. It's also very likely that testicular volume is higher than during use of only testosterone and hCG. Therefore GnRH and enclomiphene can be used in place of hCG while on TRT. The subjective results are also very encouraging, with improved libido compared to baseline and a much better sense of wellbeing. The improvements are such that it's hard to envision returning to a standard protocol, in spite of the tedium of the GnRH protocol.</p><p></p><p>There's at least the perception of a cyclical effect from the lack of nocturnal GnRH administration. This takes the form of a very subtle testicular ache early in the morning, and also a gradual improvement in mood as the day progresses. However, there's no guarantee these are real phenomena as opposed to a "nocebo" effect stemming from the knowledge that gonadotropins are dropping to low levels each night. If they are real then the only solution is to seriously consider use of an infusion pump to deliver GnRH pulses all day and all night. The significant expense is the primary deterrent.</p><p></p><p>More practically, the TRT community needs to know whether or not less frequent GnRH injections can provide benefits beyond the production of gonadotropins. That is, if you're already taking hCG with your TRT then you wouldn't bother with the enclomiphene. Instead you'd just add gonadorelin to your daily or EOD injections. Will you feel better than without? It's uncertain, because one GnRH pulse a day is a long way from the natural 16 or so. But because six pulses a day seem to work, there's at least hope. Anybody wanting to experiment should of course do it under a doctor's supervision.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 180159, member: 38109"] It's now safer to call this phase of the experiment a success: After one month without hCG there's been no loss of testicular volume. It's also very likely that testicular volume is higher than during use of only testosterone and hCG. Therefore GnRH and enclomiphene can be used in place of hCG while on TRT. The subjective results are also very encouraging, with improved libido compared to baseline and a much better sense of wellbeing. The improvements are such that it's hard to envision returning to a standard protocol, in spite of the tedium of the GnRH protocol. There's at least the perception of a cyclical effect from the lack of nocturnal GnRH administration. This takes the form of a very subtle testicular ache early in the morning, and also a gradual improvement in mood as the day progresses. However, there's no guarantee these are real phenomena as opposed to a "nocebo" effect stemming from the knowledge that gonadotropins are dropping to low levels each night. If they are real then the only solution is to seriously consider use of an infusion pump to deliver GnRH pulses all day and all night. The significant expense is the primary deterrent. More practically, the TRT community needs to know whether or not less frequent GnRH injections can provide benefits beyond the production of gonadotropins. That is, if you're already taking hCG with your TRT then you wouldn't bother with the enclomiphene. Instead you'd just add gonadorelin to your daily or EOD injections. Will you feel better than without? It's uncertain, because one GnRH pulse a day is a long way from the natural 16 or so. But because six pulses a day seem to work, there's at least hope. Anybody wanting to experiment should of course do it under a doctor's supervision. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene
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