ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Pharmacogenetics of testosterone replacement therapy
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 226734" data-attributes="member: 13851"><p><strong>Figure 2. <u>Identification of subjects with mitigated androgen effects due to longer (CAG)n in the androgen receptor gene, hence reduced testosterone-induced transcriptional activity and possible symptoms of hypogonadism</u>. Black: the HPG axis and the feedback mechanism are intact. Weaker androgen action in case of longer (CAG)n is compensated by higher LH concentrations and higher testosterone levels. The peripheral tissue remains intact. Red: any disturbance of the HPG axis or the feedback mechanism (such as [borderline] dysfunction of gonadotropin secretion, Leydig cell capacity) will attenuate the compensation for longer (CAG)n. These persons might still exhibit apparently normal testosterone concentrations, which are, nevertheless, not high enough to maintain peripheral tissue integrity. They are likely to present with symptoms of hypogonadism, albeit presenting androgen levels usually considered normal. Any investigation of the effects of the (CAG)n polymorphism of the androgen receptor gene has to focus on these men as they provide a large patient group possibly escaping attention. Evaluation of men with an intact HPG feedback mechanism conceals this clinical aspect. The same applies for the situation of complete breakdown of the HPG axis (classical hypogonadism) requiring androgen substitution. Providing low normal testosterone levels by external medication is likely to be not sufficient in cases of long (CAG)n. HPG: hypothalamic-pituitary–gonadal; LH: Luteinizing hormone.</strong></p><p><strong>[ATTACH=full]23117[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 226734, member: 13851"] [B]Figure 2. [U]Identification of subjects with mitigated androgen effects due to longer (CAG)n in the androgen receptor gene, hence reduced testosterone-induced transcriptional activity and possible symptoms of hypogonadism[/U]. Black: the HPG axis and the feedback mechanism are intact. Weaker androgen action in case of longer (CAG)n is compensated by higher LH concentrations and higher testosterone levels. The peripheral tissue remains intact. Red: any disturbance of the HPG axis or the feedback mechanism (such as [borderline] dysfunction of gonadotropin secretion, Leydig cell capacity) will attenuate the compensation for longer (CAG)n. These persons might still exhibit apparently normal testosterone concentrations, which are, nevertheless, not high enough to maintain peripheral tissue integrity. They are likely to present with symptoms of hypogonadism, albeit presenting androgen levels usually considered normal. Any investigation of the effects of the (CAG)n polymorphism of the androgen receptor gene has to focus on these men as they provide a large patient group possibly escaping attention. Evaluation of men with an intact HPG feedback mechanism conceals this clinical aspect. The same applies for the situation of complete breakdown of the HPG axis (classical hypogonadism) requiring androgen substitution. Providing low normal testosterone levels by external medication is likely to be not sufficient in cases of long (CAG)n. HPG: hypothalamic-pituitary–gonadal; LH: Luteinizing hormone. [ATTACH type="full"]23117[/ATTACH][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Pharmacogenetics of testosterone replacement therapy
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top