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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Perplexing result.. thoughts?
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<blockquote data-quote="Cataceous" data-source="post: 228711" data-attributes="member: 38109"><p>You neglect other Wiki statements: "Relative to testosterone, DHT is considerably more potent as an agonist of the androgen receptor (AR)." "... DHT may play a function in skeletal muscle amino acid transporter recruitment and function. ... Metabolites of DHT have been found to act as neurosteroids with their own AR-independent biological activity." " In bioassays, DHT has been found to be 2.5- to 10-fold more potent than testosterone."</p><p></p><p>In addition, DHT is systemically anti-estrogenic. It has aromatase-inhibiting ability, and it also works through competitive inhibition at estrogen receptors.</p><p></p><p>We've repeatedly seen lab work showing that transdermal testosterone can elevate serum DHT well above normal ranges, and sometimes manyfold above. Given the possible wide-ranging effects of such high levels I think it's unwise to suggest they don't mean anything.</p><p></p><p>Anecdotally, when I was on Androgel I experienced explosive facial and body hair growth in spite of relatively low serum testosterone. This was not in the application areas, demonstrating a clear systemic effect of higher serum DHT.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 228711, member: 38109"] You neglect other Wiki statements: "Relative to testosterone, DHT is considerably more potent as an agonist of the androgen receptor (AR)." "... DHT may play a function in skeletal muscle amino acid transporter recruitment and function. ... Metabolites of DHT have been found to act as neurosteroids with their own AR-independent biological activity." " In bioassays, DHT has been found to be 2.5- to 10-fold more potent than testosterone." In addition, DHT is systemically anti-estrogenic. It has aromatase-inhibiting ability, and it also works through competitive inhibition at estrogen receptors. We've repeatedly seen lab work showing that transdermal testosterone can elevate serum DHT well above normal ranges, and sometimes manyfold above. Given the possible wide-ranging effects of such high levels I think it's unwise to suggest they don't mean anything. Anecdotally, when I was on Androgel I experienced explosive facial and body hair growth in spite of relatively low serum testosterone. This was not in the application areas, demonstrating a clear systemic effect of higher serum DHT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Perplexing result.. thoughts?
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