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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Perplexing result.. thoughts?
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<blockquote data-quote="Cataceous" data-source="post: 228638" data-attributes="member: 38109"><p>There's nothing really concrete on the significance of a lack of diurnal variation in serum testosterone. We know that such variation is substantial in younger men and attenuates with age. From the Natesto data we know that peak testosterone levels have independent importance when it comes to avoiding symptoms of hypogonadism. There are at least a couple positive anecdotes about switching to a protocol that provides diurnal variation. I think the therapy has promise, but at this point it's mainly hypothetical and it's unclear under what conditions the possible benefits would be worth the extra effort.</p><p></p><p>The recent enanthate measurement seems sensible, though inconsistent with the ones five years ago. Ideally you'd have SHBG and albumin measurements to allow estimation of free testosterone. The working hypothesis is that free testosterone is proportional to dose. If we estimate your SHBG as 23 nMol/L and albumin as 4.6 g/dL then Vermeulen free testosterone is 0.656 nMol/L (18.9 ng/dL). Your predicted average free testosterone in nMol/L as a function of daily testosterone dose in milligrams is 0.0729 * D. My constant of proportionality is about a third larger; I have slower underlying metabolism and therefore see more free testosterone at the same dose. Your figure shouldn't be trusted too much because it's based on a single measurement and several assumptions.</p><p></p><p>It's possible that testosterone gel could be used in place of propionate. Personally I'm biased against transdermal products. The pharmacokinetics seem more variable, with some data showing really stable levels over 24 hours, but other reports suggesting high variation. The considerable DHT production is a confounding factor. Regarding dosing, I'd say to initially assume 10% absorption and go from there. But I have no idea on the variability factor needed to select the ratio versus the injected ester. You'd have to gather some data to get an idea.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 228638, member: 38109"] There's nothing really concrete on the significance of a lack of diurnal variation in serum testosterone. We know that such variation is substantial in younger men and attenuates with age. From the Natesto data we know that peak testosterone levels have independent importance when it comes to avoiding symptoms of hypogonadism. There are at least a couple positive anecdotes about switching to a protocol that provides diurnal variation. I think the therapy has promise, but at this point it's mainly hypothetical and it's unclear under what conditions the possible benefits would be worth the extra effort. The recent enanthate measurement seems sensible, though inconsistent with the ones five years ago. Ideally you'd have SHBG and albumin measurements to allow estimation of free testosterone. The working hypothesis is that free testosterone is proportional to dose. If we estimate your SHBG as 23 nMol/L and albumin as 4.6 g/dL then Vermeulen free testosterone is 0.656 nMol/L (18.9 ng/dL). Your predicted average free testosterone in nMol/L as a function of daily testosterone dose in milligrams is 0.0729 * D. My constant of proportionality is about a third larger; I have slower underlying metabolism and therefore see more free testosterone at the same dose. Your figure shouldn't be trusted too much because it's based on a single measurement and several assumptions. It's possible that testosterone gel could be used in place of propionate. Personally I'm biased against transdermal products. The pharmacokinetics seem more variable, with some data showing really stable levels over 24 hours, but other reports suggesting high variation. The considerable DHT production is a confounding factor. Regarding dosing, I'd say to initially assume 10% absorption and go from there. But I have no idea on the variability factor needed to select the ratio versus the injected ester. You'd have to gather some data to get an idea. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Perplexing result.. thoughts?
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