ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Perplexing result.. thoughts?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 216399" data-attributes="member: 38109"><p>I've attached the spreadsheet so you can look at the equations. Ignore the "TE" fields, since this is only for propionate. The inputs are your measured testosterone "T", your dose, "TP d", and measurement time post-injection, "Hours". Testosterone dose from propionate, "TP", is calculated as the dose times 0.837, a slightly different conversion factor than what you used. "TP Hours" is the length of time of the assumed pure exponential decay. It's just "Hours" minus the "TP Peak" parameter. "TP Fraction" is the amount of decay expected during "TP Hours" according to the half-life parameter, "TP Half". "TP T" multiplies the testosterone dose by the decay fraction. Among the assumptions are that SHBG doesn't change much and testosterone remains proportional to free testosterone, so that testosterone is also proportional to dose. The constant of proportionality is the "T Scale" parameter. From the inputs and the parameters we create a predicted T field, "Prediction", which we then compare to the actual value "T", subtracting to get the "Error" field. The errors are squared and summed to get a measurement of total error, which is 170.14 in the example. Normally you'd use an optimization algorithm to minimize the error, but I just did some manual iterations to arrive at the post-peak time and half-life parameters. Aside from the many assumptions, another problem is that there's little variation in dose and post-injection time. The accuracy of the model beyond these narrow inputs is questionable and untested.</p><p></p><p>If there were going to be an unusual adverse reaction to a testosterone ester I'd think it would be along the lines of an allergic reaction, though I don't know if that's even plausible. Generally the testosterone esters are considered inert until they reach the bloodstream, where the esters are rapidly cleaved, freeing the testosterone. At that point the source of the testosterone becomes irrelevant; the molecules all act the same. It seems more likely that a symptom of anxiety is related to some hormonal and/or neurotransmitter imbalance. Unfortunately it's complex and highly individualized. Tying in to what [USER=40068]@JA Battle[/USER] said above, progesterone is calming and balances estrogen. DHEA and pregnenolone can possibly promote anxiety. Oddly, topical DHEA sends my anxiety skyrocketing, whereas oral DHEA is fine, perhaps because in the oral route it's mostly going to DHEA-S rather than DHEA.</p><p></p><p>The control of other parameters, such as morning wood and "thinking performance/energy" is also maddeningly complex. I had loss of morning wood when I was hypogonadal, but also at times on TRT when my total testosterone was ~800 ng/dL, well above average. We probably need to consider a bigger picture, one that includes testosterone, estradiol, progesterone, DHT and prolactin, along with kisspeptin/GnRH/LH/etc.</p><p></p><p>If you have important events coming up then I'd defer significant protocol tinkering until afterwards. After that I think it's worth spending significant time at somewhat lower doses to see how they compare. Adjusting this one variable is a limited action, but it can affect estradiol and DHT, and possibly prolactin as well.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 216399, member: 38109"] I've attached the spreadsheet so you can look at the equations. Ignore the "TE" fields, since this is only for propionate. The inputs are your measured testosterone "T", your dose, "TP d", and measurement time post-injection, "Hours". Testosterone dose from propionate, "TP", is calculated as the dose times 0.837, a slightly different conversion factor than what you used. "TP Hours" is the length of time of the assumed pure exponential decay. It's just "Hours" minus the "TP Peak" parameter. "TP Fraction" is the amount of decay expected during "TP Hours" according to the half-life parameter, "TP Half". "TP T" multiplies the testosterone dose by the decay fraction. Among the assumptions are that SHBG doesn't change much and testosterone remains proportional to free testosterone, so that testosterone is also proportional to dose. The constant of proportionality is the "T Scale" parameter. From the inputs and the parameters we create a predicted T field, "Prediction", which we then compare to the actual value "T", subtracting to get the "Error" field. The errors are squared and summed to get a measurement of total error, which is 170.14 in the example. Normally you'd use an optimization algorithm to minimize the error, but I just did some manual iterations to arrive at the post-peak time and half-life parameters. Aside from the many assumptions, another problem is that there's little variation in dose and post-injection time. The accuracy of the model beyond these narrow inputs is questionable and untested. If there were going to be an unusual adverse reaction to a testosterone ester I'd think it would be along the lines of an allergic reaction, though I don't know if that's even plausible. Generally the testosterone esters are considered inert until they reach the bloodstream, where the esters are rapidly cleaved, freeing the testosterone. At that point the source of the testosterone becomes irrelevant; the molecules all act the same. It seems more likely that a symptom of anxiety is related to some hormonal and/or neurotransmitter imbalance. Unfortunately it's complex and highly individualized. Tying in to what [USER=40068]@JA Battle[/USER] said above, progesterone is calming and balances estrogen. DHEA and pregnenolone can possibly promote anxiety. Oddly, topical DHEA sends my anxiety skyrocketing, whereas oral DHEA is fine, perhaps because in the oral route it's mostly going to DHEA-S rather than DHEA. The control of other parameters, such as morning wood and "thinking performance/energy" is also maddeningly complex. I had loss of morning wood when I was hypogonadal, but also at times on TRT when my total testosterone was ~800 ng/dL, well above average. We probably need to consider a bigger picture, one that includes testosterone, estradiol, progesterone, DHT and prolactin, along with kisspeptin/GnRH/LH/etc. If you have important events coming up then I'd defer significant protocol tinkering until afterwards. After that I think it's worth spending significant time at somewhat lower doses to see how they compare. Adjusting this one variable is a limited action, but it can affect estradiol and DHT, and possibly prolactin as well. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Perplexing result.. thoughts?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top