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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Permanently crashed my e2
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<blockquote data-quote="zancek0" data-source="post: 258871" data-attributes="member: 45189"><p>If it is any consolation, you're not alone. There's about a dozen people on this forum who reported long term AI induced low e2 symptoms. Hopefully we can eventually figure out how to resolve this. As of now, there have been some positive reports on e2 supplementation (oral e2 and injectable e2). Maybe that's something you wanna try alongside a steady TRT protocol. I have not yet experimented with exogenous e2 but will do so in the future.</p><p>There's been some talk about the e2 crash possibly inducing epigenetic changes that rendered estrogen receptors less responsive (so despite normal serum e2 levels you still feel low e2 symptoms). It's the most "logical" conclusion, I suppose. In theory and proven in some studies, such epigenetic changes are reversible. In layman's terms what could help is providing the body with excess levels of e2 to "wake up" estrogen receptors, so to speak. But what could also help is using some natural compounds that have been proved to reverse epigenetic changes in terms of repression of relevant genes. EGCG, curcumin, resveratrol, sulforaphane ... are some examples.</p><p></p><p></p><p>However, it's worth noting that all these symptoms you experience also present in people with various chronic conditions characterized by chronic inflammation. I am right now researching the possibility of e2 deprivation and consequent androgen excess inducing what I proposed here: <a href="https://thinksteroids.com/community/threads/aromasin-ruined-me-for-good.134417240/post-3133527" target="_blank">Aromasin ruined me for good..</a></p><p></p><p></p><p>Do you perhaps have some labs showing tt, free t, e2, dht, shbg, dhea, thyroid, ferritin, vit D, cholesterol levels (and whatever else you've tested since the crash, maybe folate and b12 levels or whatever else)? I know you said that the labs show ok levels but I am curious.</p></blockquote><p></p>
[QUOTE="zancek0, post: 258871, member: 45189"] If it is any consolation, you're not alone. There's about a dozen people on this forum who reported long term AI induced low e2 symptoms. Hopefully we can eventually figure out how to resolve this. As of now, there have been some positive reports on e2 supplementation (oral e2 and injectable e2). Maybe that's something you wanna try alongside a steady TRT protocol. I have not yet experimented with exogenous e2 but will do so in the future. There's been some talk about the e2 crash possibly inducing epigenetic changes that rendered estrogen receptors less responsive (so despite normal serum e2 levels you still feel low e2 symptoms). It's the most "logical" conclusion, I suppose. In theory and proven in some studies, such epigenetic changes are reversible. In layman's terms what could help is providing the body with excess levels of e2 to "wake up" estrogen receptors, so to speak. But what could also help is using some natural compounds that have been proved to reverse epigenetic changes in terms of repression of relevant genes. EGCG, curcumin, resveratrol, sulforaphane ... are some examples. However, it's worth noting that all these symptoms you experience also present in people with various chronic conditions characterized by chronic inflammation. I am right now researching the possibility of e2 deprivation and consequent androgen excess inducing what I proposed here: [URL='https://thinksteroids.com/community/threads/aromasin-ruined-me-for-good.134417240/post-3133527']Aromasin ruined me for good..[/URL] Do you perhaps have some labs showing tt, free t, e2, dht, shbg, dhea, thyroid, ferritin, vit D, cholesterol levels (and whatever else you've tested since the crash, maybe folate and b12 levels or whatever else)? I know you said that the labs show ok levels but I am curious. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Permanently crashed my e2
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