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Let's see you cite some examples. In our last outing you stormed out without asking for evidence. But if you're asking now then I'm happy to share some other references that your friend readalot/tareload provided.

The basics are encapsulated in this quote:

However, as discussed in Chapter 5, unbound drug concentrations will not be affected by decreases in the protein binding of restrictively metabolized drugs. Therefore, no dosage alterations are required for these drugs when protein binding is the only parameter that is changed.[R]

Here's another good one:

However, steady-state concentrations of unbound drug will be unchanged as long as there is no change in CLint.[R]

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