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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Peak & Trough levels for TRT
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<blockquote data-quote="madman" data-source="post: 193464" data-attributes="member: 13851"><p>Regarding half-lives keep in mind that a majority of studies on the pharmacokinetics of the various T-esters were done using IM, not sub-q injections.</p><p></p><p>I would not get too caught up on the half-life between IM vs sub-q and you should have no issues injecting TE let alone TC sub-q once weekly as long as your trough TT level is in a healthy range and you feel well overall and are not experiencing any side-effects let alone blood markers are healthy!</p><p></p><p>The downfall may be if you were to run too high a trough level then your peak TT/FT let alone e2 will be higher which could cause issues for some.</p><p></p><p>Some men do well and prefer once-weekly injections using TE or TC (sub-q or IM).</p><p></p><p>Comes down to the individual and one's SHBG level can have a big impact on the protocol chosen.</p><p></p><p>Whether one chooses to inject once weekly, M/W/F, twice weekly (every 3.5 days), EOD, or daily the peak--->trough levels need to be kept in mind.</p><p></p><p>Depending on one where one SHBG sits some may feel better overall injecting more frequently which will not only clip the peak--->trough but blood levels will be more stable.</p><p></p><p></p><p></p><p></p><p>post#8</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/subq-experience.19663/#post-159629[/URL]</p><p></p><p>my reply to Systemlord:</p><p></p><p></p><p></p><p>Hope you understand that when injected sub-q the esterified T does not convert to E2 until the ester has been cleaved......which happens only when it enters the bloodstream and as stated below....."<strong>Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed"</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>"PRODRUG HYDROLYSIS WILL ONLY OCCUR IN BLOOD"</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>CONCLUSIONS</strong></p><p></p><p>It is interesting to realize that drug absorption from an oil depot cannot entirely be described by a simple two-phase mass transfer model where concentration gradients, diffusion, and partition coefficients would enable the calculation of the expected absorption. <strong><u>It is demonstrated in this dissertation that there is a role of the excipient BOH in yielding an initially high absorption</u>.</strong> <strong><u>The oil depot forms a continuous phase after injection but will be dispersed and encapsulated at the injection site after some days. This in turn largely influences the way the prodrug becomes available; after release from the oil depot, it is present in the interstitial fluid which is drained through the lymph into the systemic circulation</u>. Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed. Both the lymph transport and the cell wall permeation take time which is expressed in a lag time. <u>This lag time is different for each injection site: a subcutaneously administered prodrug will enter the systemic circulation via a short path and at a low drainage flow</u>. <u>This results in a short lag time and a slow absorption rate constant of the prodrug</u>.</strong> <strong><u>Deeper administered prodrugs (i.e. intramuscular injections) are suggested to be absorbed via a longer path, but at a higher flow, which results in a longer lag time but a higher absorption rate constant of the prodrug</u>.</strong></p><p></p><p></p><p>[ATTACH=full]12380[/ATTACH]</p><p><strong>Figure 7.2: Schematic overview of the new insights into drug absorption from oil depots. After release from the oil depot (yellow circle at the injection site),</strong> <strong>the prodrug is transferred towards the central compartment via the lymphatic system. Here, it will be hydrolyzed to the active substance (see circle). ka = absorption rate constant; ke = elimination rate constant.</strong></p></blockquote><p></p>
[QUOTE="madman, post: 193464, member: 13851"] Regarding half-lives keep in mind that a majority of studies on the pharmacokinetics of the various T-esters were done using IM, not sub-q injections. I would not get too caught up on the half-life between IM vs sub-q and you should have no issues injecting TE let alone TC sub-q once weekly as long as your trough TT level is in a healthy range and you feel well overall and are not experiencing any side-effects let alone blood markers are healthy! The downfall may be if you were to run too high a trough level then your peak TT/FT let alone e2 will be higher which could cause issues for some. Some men do well and prefer once-weekly injections using TE or TC (sub-q or IM). Comes down to the individual and one's SHBG level can have a big impact on the protocol chosen. Whether one chooses to inject once weekly, M/W/F, twice weekly (every 3.5 days), EOD, or daily the peak--->trough levels need to be kept in mind. Depending on one where one SHBG sits some may feel better overall injecting more frequently which will not only clip the peak--->trough but blood levels will be more stable. post#8 [URL unfurl="true"]https://www.excelmale.com/forum/threads/subq-experience.19663/#post-159629[/URL] my reply to Systemlord: Hope you understand that when injected sub-q the esterified T does not convert to E2 until the ester has been cleaved......which happens only when it enters the bloodstream and as stated below....."[B]Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed" "PRODRUG HYDROLYSIS WILL ONLY OCCUR IN BLOOD" CONCLUSIONS[/B] It is interesting to realize that drug absorption from an oil depot cannot entirely be described by a simple two-phase mass transfer model where concentration gradients, diffusion, and partition coefficients would enable the calculation of the expected absorption. [B][U]It is demonstrated in this dissertation that there is a role of the excipient BOH in yielding an initially high absorption[/U].[/B] [B][U]The oil depot forms a continuous phase after injection but will be dispersed and encapsulated at the injection site after some days. This in turn largely influences the way the prodrug becomes available; after release from the oil depot, it is present in the interstitial fluid which is drained through the lymph into the systemic circulation[/U]. Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed. Both the lymph transport and the cell wall permeation take time which is expressed in a lag time. [U]This lag time is different for each injection site: a subcutaneously administered prodrug will enter the systemic circulation via a short path and at a low drainage flow[/U]. [U]This results in a short lag time and a slow absorption rate constant of the prodrug[/U].[/B] [B][U]Deeper administered prodrugs (i.e. intramuscular injections) are suggested to be absorbed via a longer path, but at a higher flow, which results in a longer lag time but a higher absorption rate constant of the prodrug[/U].[/B] [ATTACH type="full" alt="Screenshot (3157).png"]12380[/ATTACH] [B]Figure 7.2: Schematic overview of the new insights into drug absorption from oil depots. After release from the oil depot (yellow circle at the injection site),[/B] [B]the prodrug is transferred towards the central compartment via the lymphatic system. Here, it will be hydrolyzed to the active substance (see circle). ka = absorption rate constant; ke = elimination rate constant.[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Peak & Trough levels for TRT
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