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PDE5 - The Elephant in the Room ?
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<blockquote data-quote="The Dude" data-source="post: 13403" data-attributes="member: 2592"><p>Aha! I had to go to the legal documents for the lawsuit over Viagra by Pfizer against Teva from 2011. There I found statements of fact that are carefully checked for accuracy, because Pfizer do not want their decision thrown out over a technicality. Here are the quotes:</p><p></p><p> </p><p></p><p>There was a footnote to this:</p><p></p><p> </p><p></p><p>Yes, it is true that clogged arteries (and other conditions) can cause insufficient nitric oxide in the system, and those people with those conditions would see benefit from nitric oxide generating supplements.</p><p></p><p>However, it is clear that Pfizer's research indicates that most ED is due to <strong>excess PDE5</strong> - not a lack of nitric oxide.</p><p></p><p>In fact, those who have a lack of nitric oxide do not benefit from PDE5 inhibitors, because they are not producing cGMP, so it does not matter whether PDE5 is inhibited or not.</p><p></p><p>And, in fact, a significant minority (something like 30-40% IIRC) do not benefit from Viagra or Cialis, precisely because they are not generating enough nitric oxide.</p><p></p><p>But - for those who do respond to Viagra and Cialis, then it seems clear that their problem is <strong>excess PDE5</strong> - we see this confirmed by Pfizer themselves.</p><p></p><p>So, why has there been so little mention of the problem of <strong>excess PDE5</strong> - including its origin and prevention ?</p><p></p><p>I think there are two possible reasons:</p><p></p><p>1 - Viagra and Cialis are big business world-wide. They are sold for $20 and wholesale for $0.30. There is a big motivation to just sell people pills, rather than do anything to prevent the condition (this is also true of many other conditions).</p><p></p><p>2 - If there is research into the origin of the condition of <strong>excess PDE5</strong>, then it is undoubtedly being done very quietly, so that whoever comes up with a treatment can patent it.</p><p></p><p>(NOTE: This does not mean that there are not many benefits to increasing nitric oxide, but simply to say that in the case of ED, if Viagra or Cialis work, then the problem is <strong>excess PDE5</strong>, not insufficient nitric oxide.)</p></blockquote><p></p>
[QUOTE="The Dude, post: 13403, member: 2592"] Aha! I had to go to the legal documents for the lawsuit over Viagra by Pfizer against Teva from 2011. There I found statements of fact that are carefully checked for accuracy, because Pfizer do not want their decision thrown out over a technicality. Here are the quotes: There was a footnote to this: Yes, it is true that clogged arteries (and other conditions) can cause insufficient nitric oxide in the system, and those people with those conditions would see benefit from nitric oxide generating supplements. However, it is clear that Pfizer's research indicates that most ED is due to [B]excess PDE5[/B] - not a lack of nitric oxide. In fact, those who have a lack of nitric oxide do not benefit from PDE5 inhibitors, because they are not producing cGMP, so it does not matter whether PDE5 is inhibited or not. And, in fact, a significant minority (something like 30-40% IIRC) do not benefit from Viagra or Cialis, precisely because they are not generating enough nitric oxide. But - for those who do respond to Viagra and Cialis, then it seems clear that their problem is [B]excess PDE5[/B] - we see this confirmed by Pfizer themselves. So, why has there been so little mention of the problem of [B]excess PDE5[/B] - including its origin and prevention ? I think there are two possible reasons: 1 - Viagra and Cialis are big business world-wide. They are sold for $20 and wholesale for $0.30. There is a big motivation to just sell people pills, rather than do anything to prevent the condition (this is also true of many other conditions). 2 - If there is research into the origin of the condition of [B]excess PDE5[/B], then it is undoubtedly being done very quietly, so that whoever comes up with a treatment can patent it. (NOTE: This does not mean that there are not many benefits to increasing nitric oxide, but simply to say that in the case of ED, if Viagra or Cialis work, then the problem is [B]excess PDE5[/B], not insufficient nitric oxide.) [/QUOTE]
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PDE5 - The Elephant in the Room ?
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