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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Pathophysiology of Benign Prostatic Hyperplasia and Benign Prostatic Enlargement: A Mini-Review
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<blockquote data-quote="madman" data-source="post: 144783" data-attributes="member: 13851"><p><strong><span style="color: rgb(40, 50, 78)">Abstract</span></strong></p><p><strong><span style="color: rgb(184, 49, 47)">Benign prostatic hyperplasia (BPH), benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) </span><span style="color: rgb(0, 0, 0)">belong to the most frequent</span><span style="color: rgb(184, 49, 47)"> diseases </span><span style="color: rgb(0, 0, 0)">in</span><span style="color: rgb(184, 49, 47)"> ageing men.</span></strong> Beyond the 6th decade of life, more than 30% of men suffer from moderate to severe LUTS requiring intervention. <strong>The <span style="color: rgb(184, 49, 47)">pathophysiology</span> of <span style="color: rgb(184, 49, 47)">BPH/BPE</span> is still <span style="color: rgb(184, 49, 47)">incompletely </span>understood. </strong>The dominant role of the androgen system and the androgen receptor is well defined. Androgen receptors are expressed in BPH tissue in which they are activated by the potent androgen dihydrotestosterone. Synthesis of dihydrotestosterone is under control of the 5α-reductase enzyme, activity of which is antagonized by finasteride and dutasteride. <strong>More recently, the impact of <span style="color: rgb(184, 49, 47)">prostatic inflammation</span> and <span style="color: rgb(184, 49, 47)">metabolic parameters </span>particularly for the development of <span style="color: rgb(184, 49, 47)">BPE</span> and <span style="color: rgb(184, 49, 47)">LUTS</span> has increasingly been recognized.</strong> A better understanding of the pathophysiology is a prerequisite for the development of novel, more effective medical treatment options.</p><p></p><p></p><p></p><p></p><p>[ATTACH=full]7219[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 144783, member: 13851"] [B][COLOR=rgb(40, 50, 78)]Abstract[/COLOR] [COLOR=rgb(184, 49, 47)]Benign prostatic hyperplasia (BPH), benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) [/COLOR][COLOR=rgb(0, 0, 0)]belong to the most frequent[/COLOR][COLOR=rgb(184, 49, 47)] diseases [/COLOR][COLOR=rgb(0, 0, 0)]in[/COLOR][COLOR=rgb(184, 49, 47)] ageing men.[/COLOR][/B] Beyond the 6th decade of life, more than 30% of men suffer from moderate to severe LUTS requiring intervention. [B]The [COLOR=rgb(184, 49, 47)]pathophysiology[/COLOR] of [COLOR=rgb(184, 49, 47)]BPH/BPE[/COLOR] is still [COLOR=rgb(184, 49, 47)]incompletely [/COLOR]understood. [/B]The dominant role of the androgen system and the androgen receptor is well defined. Androgen receptors are expressed in BPH tissue in which they are activated by the potent androgen dihydrotestosterone. Synthesis of dihydrotestosterone is under control of the 5α-reductase enzyme, activity of which is antagonized by finasteride and dutasteride. [B]More recently, the impact of [COLOR=rgb(184, 49, 47)]prostatic inflammation[/COLOR] and [COLOR=rgb(184, 49, 47)]metabolic parameters [/COLOR]particularly for the development of [COLOR=rgb(184, 49, 47)]BPE[/COLOR] and [COLOR=rgb(184, 49, 47)]LUTS[/COLOR] has increasingly been recognized.[/B] A better understanding of the pathophysiology is a prerequisite for the development of novel, more effective medical treatment options. [ATTACH=full]7219[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Pathophysiology of Benign Prostatic Hyperplasia and Benign Prostatic Enlargement: A Mini-Review
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