Parathyroid Hormone Roles and Testing

Nelson Vergel

Founder, ExcelMale.com
As a result of its slow & yet rapid effect on bones and kidneys, Parathyroid hormone can alter calcium levels in the blood within few seconds & also sustain it for several weeks and months. In the case where there is any form of chronic calcium deficiency - the parathyroid gland will increase in size. This will stay in place for sustained PTH secretion.

Parathyroid glands control calcium volume within the blood and bones and its main role is to maintain the calcium level of the body within narrow range. This helps the nervous and muscular systems to function appropriately. When the calcium level of blood drops below a certain range, calcium-activated receptors found within the parathyroid gland get triggered to release PTH into the blood.

Roles of (PTH) Parathyroid Hormone

To fully comprehend the role of parathyroid hormone in the human body system, it is essential to understand calcium & phosphate metabolism. Realistically, there are about 99 percent of the body’s calcium & 85 percent of phosphate stored within the bones. Practically, these compounds don’t only impact the bone, but they play several vital functions within the body in much smaller quantities than what is stored within the bones. When there is a minor change in calcium levels, this will instantly have an impact on the body, though changes won’t be immediately apparent with respect to phosphate levels.

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Nice summary Nelson. A more complete panel with Ca2+, Pi, Vitamin D, Calcitonin, and FGF23 would be very cool. Although, the FGF23 would be very expensive.
 
Is it true that low very low E2 levels negatively affect Parathyroid Hormone levels and consequently result in bone loss?
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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