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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Paradox TRT results, very low SHBG
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<blockquote data-quote="tareload" data-source="post: 247201"><p>Seems this has been posted to death on here thanks to [USER=38109]@Cataceous[/USER] 's heroic efforts.</p><p></p><p>How would decreasing SHBG increase or "free" up more T after the initial transient and the patient reaches new stable operating point?</p><p></p><p>See here for exhaustive posts I shared with you.</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/shbg-and-free-testosterone-everything-you-need-to-know.27039/post-246243[/URL]</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/shbg-and-free-testosterone-everything-you-need-to-know.27039/post-246246[/URL]</p><p></p><p></p><p>Are you invoking a hypothesis that involves SHBG providing feedback to the HPTA control loop? Simply stating SHBG frees up more T appears handwaving once you understand..</p><p></p><p></p><p>TT = f(FT,SHBG,HSA)</p><p></p><p>not</p><p></p><p>FT = f(TT,SHBG,HSA) like the calculator paradigm tht is a result of evolution of measurement methods over time.</p><p></p><p>Testes produce FT not TT. Substrate for aromatization is FT not TT. Body eliminates FT not TT.</p><p></p><p>Hence reducing SHBG would have to increase the signal to produce more FT in order to free up more absolute T. For a given FT production rate, it is correct to state that lowering SHBG would result in a higher percentage of FT (FT/TT). That is very different picture than more absolute FT. See exhaustive commentary and posts linked above.</p><p></p><p>At some point we need to have one thread to cover pro/con on this debate so we can put this to bed to help guys and avoid confusing the crap out of most laypeople. Otherwise the same myths keep getting repeated over and over again. I posted my experiment using oxandrolone. Oxandrolone dropped SHBG but <strong>reducing SHBG did not increase absolute FT. </strong> It stayed constant. TT dropped as expected. Hence, FT/TT increased (relative fraction of FT went up).</p></blockquote><p></p>
[QUOTE="tareload, post: 247201"] Seems this has been posted to death on here thanks to [USER=38109]@Cataceous[/USER] 's heroic efforts. How would decreasing SHBG increase or "free" up more T after the initial transient and the patient reaches new stable operating point? See here for exhaustive posts I shared with you. [URL unfurl="true"]https://www.excelmale.com/forum/threads/shbg-and-free-testosterone-everything-you-need-to-know.27039/post-246243[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/shbg-and-free-testosterone-everything-you-need-to-know.27039/post-246246[/URL] Are you invoking a hypothesis that involves SHBG providing feedback to the HPTA control loop? Simply stating SHBG frees up more T appears handwaving once you understand.. TT = f(FT,SHBG,HSA) not FT = f(TT,SHBG,HSA) like the calculator paradigm tht is a result of evolution of measurement methods over time. Testes produce FT not TT. Substrate for aromatization is FT not TT. Body eliminates FT not TT. Hence reducing SHBG would have to increase the signal to produce more FT in order to free up more absolute T. For a given FT production rate, it is correct to state that lowering SHBG would result in a higher percentage of FT (FT/TT). That is very different picture than more absolute FT. See exhaustive commentary and posts linked above. At some point we need to have one thread to cover pro/con on this debate so we can put this to bed to help guys and avoid confusing the crap out of most laypeople. Otherwise the same myths keep getting repeated over and over again. I posted my experiment using oxandrolone. Oxandrolone dropped SHBG but [B]reducing SHBG did not increase absolute FT. [/B] It stayed constant. TT dropped as expected. Hence, FT/TT increased (relative fraction of FT went up). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Paradox TRT results, very low SHBG
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