Man, I feel for you and wish you good luck. What a complicated set of things to sort out let alone actually treat.
How old are you and is this something that initially occurred randomly or acutely, or long term in onset?
Is it attributable solely to a random tumor or are there other genetic or hereditary associations?
Re: your question about DHEA, pregenelone etc, You are probably going to get very differing views about this from forum members. I'll just say this: If you look at the sex hormone pathways, it all starts with cholesterol, so if there is anything in your situation which effects cholesterol levels, that would need to be addressed. Then likewise every step down the chain.
It seems pretty well known that when you are on Testosterone replacement, and LH shuts down, pregnenelone and DHEA production is curtailed or at least reduced as well. So yeah, possible replacement with OTC pregnenelone and DHEA may be in order, and many on TRT are prescribed these as such. However, HCG is also commonly used for testicular comfort and to "backfill the pathways" meaning stimulate production of Pregnenelone and DHEA as well. Everyone is different in how they react to any/all of these treatments, and all three tend to push estradiol higher. So they are definite considerations in your case, but really need to be managed through trial and error dosage and blood testing to monitor in order to readjust as needed.
