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Androgens and SARMs upregulate SR-B1 and that drives down total HDL-C, the question remains, does the decrease of total HDL as a function of androgens really increased CAD risk? I don't think it does. Now if someone is taking large doses of a C-17 androgen and their HDL is 5, that could be a different story, but they'd likely die of HCA before they die of CAD.