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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Oxandrolone and Joints
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<blockquote data-quote="madman" data-source="post: 190999" data-attributes="member: 13851"><p>When it comes to tendon health I would be more concerned with your e2.</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/sex-hormones-and-tendon.8052/#post-156589[/URL]</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/effect-of-estrogen-on-musculoskeletal-performance-and-injury-risk.17635/[/URL]</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/the-effect-of-estrogen-on-tendon-and-ligament-metabolism-and-function.12876/[/URL]</p><p></p><p></p><p></p><p></p><p></p><p><strong>Anabolic steroids and tendons: <span style="color: rgb(184, 49, 47)">A review of their mechanical, structural, and biologic effects </span><span style="color: rgb(0, 0, 0)">(2018)</span></strong></p><p><strong></strong></p><p></p><p>[URL unfurl="true"]https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116[/URL]</p><p></p><p></p><p></p><p><strong>Discussion</strong></p><p></p><p><em><strong><span style="color: rgb(184, 49, 47)">Although rigorous studies linking AAS use to tendon rupture are still needed, the notion that supraphysiologic doses of AAS predispose tendon to rupture by reducing elasticity is widely reported in the literature. </span></strong></em><span style="color: rgb(44, 130, 201)"><em><strong>Two alternatives (though not mutually exclusive) hypotheses are often invoked to explain AAS‐associated tendon rupture.<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0034" target="_blank">34</a>, <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0090" target="_blank">90</a>, <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0102" target="_blank">102</a>, <a href="https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0103" target="_blank">103</a></strong></em></span> <span style="color: rgb(26, 188, 156)"><strong><em>The <u>first hypothesis</u> posits that AAS has a little‐to‐no deleterious effect on tendons themselves. Instead, muscular hypertrophy, without a corresponding strengthening of the associated tendons, explains tendon‐associated rupture. </em></strong><em><strong>The <u>second hypothesis</u> is that, at high doses, particularly in conjunction with physical exertion, AAS damage the structure of the tendons and makes them more vulnerable to rupture, even in the absence of excessive stress. </strong></em></span><span style="color: rgb(184, 49, 47)"><strong><em><u>This review demonstrates that neither hypothesis can be confirmed or denied based on the currently available evidence. Moreover, it is unclear how factors like stacking, dosing, and exercise influence tendon stiffness</u>.</em></strong></span></p><p></p><p></p><p></p><p></p><p><strong>Conclusion</strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><em><u><strong>Despite roughly</strong></u></em></span><strong><span style="color: rgb(184, 49, 47)"><u> 30 years of research, AAS‐associated tendon pathology/injury is still poorly understood</u>.</span></strong><span style="color: rgb(44, 130, 201)"><strong> While several studies have linked increased tendon stiffness to AAS use, the data are far from conclusive and a distinction should be made between loss of elasticity and actual tendon rupture. Moreover, no consistent AAS‐induced ultrastructural or biochemical alterations have been found to account for the changes in biomechanical properties, and the limited, often contradictory results preclude firm conclusions. </strong></span><strong><span style="color: rgb(26, 188, 156)">Current research is taking a second look at AAS as potential therapeutic agents for patients with a severe tendon injury. Despite being reasonably supported by reports indicating that AAS may counteract the irreparable structural/functional changes that occur in the musculotendinous unit following rotator cuff tears, <u>no studies reporting on the structural, biological, or mechanical effects of AAS on tendon have investigated their use as potential therapeutic agents</u>. </span></strong><span style="color: rgb(184, 49, 47)"><em><strong><u>Rather than providing strong evidence for or against the use of AAS, this review highligh</u></strong></em></span><strong><em><span style="color: rgb(184, 49, 47)"><u>ts the need for additional studies</u>. Potential areas for future research include studies aimed at understanding dose‐ and drug‐dependent responses. <u>There is also reasonable evidence to support further studies investigating the use of AAS following rotator cuff injury, although no studies to date have explicitly shown that AAS has beneficial effects on the structural, biological, or mechanical properties of tendon</u>. Other potential areas for future research include studies aimed at better understanding the effects of stacking and ultra‐high treatment regimens, which are often used by recreational abusers. </span></em></strong></p><p></p><p></p><p></p><p></p></blockquote><p></p>
[QUOTE="madman, post: 190999, member: 13851"] When it comes to tendon health I would be more concerned with your e2. [URL unfurl="true"]https://www.excelmale.com/forum/threads/sex-hormones-and-tendon.8052/#post-156589[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/effect-of-estrogen-on-musculoskeletal-performance-and-injury-risk.17635/[/URL] [URL unfurl="true"]https://www.excelmale.com/forum/threads/the-effect-of-estrogen-on-tendon-and-ligament-metabolism-and-function.12876/[/URL] [B]Anabolic steroids and tendons: [COLOR=rgb(184, 49, 47)]A review of their mechanical, structural, and biologic effects [/COLOR][COLOR=rgb(0, 0, 0)](2018)[/COLOR] [/B] [URL unfurl="true"]https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116[/URL] [B]Discussion[/B] [I][B][COLOR=rgb(184, 49, 47)]Although rigorous studies linking AAS use to tendon rupture are still needed, the notion that supraphysiologic doses of AAS predispose tendon to rupture by reducing elasticity is widely reported in the literature. [/COLOR][/B][/I][COLOR=rgb(44, 130, 201)][I][B]Two alternatives (though not mutually exclusive) hypotheses are often invoked to explain AAS‐associated tendon rupture.[URL='https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0034']34[/URL], [URL='https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0090']90[/URL], [URL='https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0102']102[/URL], [URL='https://onlinelibrary.wiley.com/doi/full/10.1002/jor.24116#jor24116-bib-0103']103[/URL][/B][/I][/COLOR] [COLOR=rgb(26, 188, 156)][B][I]The [U]first hypothesis[/U] posits that AAS has a little‐to‐no deleterious effect on tendons themselves. Instead, muscular hypertrophy, without a corresponding strengthening of the associated tendons, explains tendon‐associated rupture. [/I][/B][I][B]The [U]second hypothesis[/U] is that, at high doses, particularly in conjunction with physical exertion, AAS damage the structure of the tendons and makes them more vulnerable to rupture, even in the absence of excessive stress. [/B][/I][/COLOR][COLOR=rgb(184, 49, 47)][B][I][U]This review demonstrates that neither hypothesis can be confirmed or denied based on the currently available evidence. Moreover, it is unclear how factors like stacking, dosing, and exercise influence tendon stiffness[/U].[/I][/B][/COLOR] [B]Conclusion[/B] [COLOR=rgb(184, 49, 47)][I][U][B]Despite roughly[/B][/U][/I][/COLOR][B][COLOR=rgb(184, 49, 47)][U] 30 years of research, AAS‐associated tendon pathology/injury is still poorly understood[/U].[/COLOR][/B][COLOR=rgb(44, 130, 201)][B] While several studies have linked increased tendon stiffness to AAS use, the data are far from conclusive and a distinction should be made between loss of elasticity and actual tendon rupture. Moreover, no consistent AAS‐induced ultrastructural or biochemical alterations have been found to account for the changes in biomechanical properties, and the limited, often contradictory results preclude firm conclusions. [/B][/COLOR][B][COLOR=rgb(26, 188, 156)]Current research is taking a second look at AAS as potential therapeutic agents for patients with a severe tendon injury. Despite being reasonably supported by reports indicating that AAS may counteract the irreparable structural/functional changes that occur in the musculotendinous unit following rotator cuff tears, [U]no studies reporting on the structural, biological, or mechanical effects of AAS on tendon have investigated their use as potential therapeutic agents[/U]. [/COLOR][/B][COLOR=rgb(184, 49, 47)][I][B][U]Rather than providing strong evidence for or against the use of AAS, this review highligh[/U][/B][/I][/COLOR][B][I][COLOR=rgb(184, 49, 47)][U]ts the need for additional studies[/U]. Potential areas for future research include studies aimed at understanding dose‐ and drug‐dependent responses. [U]There is also reasonable evidence to support further studies investigating the use of AAS following rotator cuff injury, although no studies to date have explicitly shown that AAS has beneficial effects on the structural, biological, or mechanical properties of tendon[/U]. Other potential areas for future research include studies aimed at better understanding the effects of stacking and ultra‐high treatment regimens, which are often used by recreational abusers. [/COLOR][/I][/B] [COLOR=rgb(184, 49, 47)][B][I] [/I][/B][/COLOR] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Oxandrolone and Joints
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