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Pain Management Research
Osteoarthritis and adding nandrolone to TRT
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<blockquote data-quote="BigTex" data-source="post: 221079" data-attributes="member: 43589"><p>Since this subject came up, does being an athlete lead to osteoarthritis or is this perhaps due to injury, genetic factors, age? Remember 60% of people over the age of 50 end up with having problems to some degree. So does bodybuilding and powerlifting really cause osteoarthritis?</p><p></p><p>Sandmeier, Robert H.<strong> “Osteoarthritis and Exercise: Does Increased Activity Wear Out Joints?.”</strong> <em>The Permanente Journal</em> vol. 4,4 (2000): 26–28. </p><p></p><p>Full study</p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/[/URL]</p><p></p><p>Several authors have attempted to differentiate between weightbearing and nonweightbearing activity. Sohn and Micheli<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b15-permj-4-4-26" target="_blank">15</a> attempted to control for the effect of weightbearing exercise by comparing 504 former college runners with 287 swimmers and found no difference in the incidence of osteoarthritis. Kujala et al<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26" target="_blank">16</a> found radiographic signs of osteoarthritis in 3% of the shooters studied, 29% of the soccer players, 31% of the weightlifters, and 14% of the runners. The authors<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26" target="_blank">16</a> felt that the majority of the differences in the incidence of osteoarthritis could be explained by the higher rate of injury in soccer players and by increased body weight in weightlifters.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26" target="_blank">16</a> Knee injuries resulted in a fivefold increased risk of osteoarthritis.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26" target="_blank">16</a> Kujala et al<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b17-permj-4-4-26" target="_blank">17</a> also reported on 2049 athletes who competed in the Olympic Games from 1920 to 1965, comparing the athletes with 1403 matched controls. In this study, the endpoint (presenting for joint replacement) takes into account symptoms as well as radiographic criteria. Endurance athletes (runners) had a relative risk of 1.73, participants in mixed-type sports (ex-soccer players) had a relative risk of 1.9, and participants in power sports (weightlifting, wrestling) had a relative risk of 2.17.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b17-permj-4-4-26" target="_blank">17</a> Incidence of injury was not reported.</p><h2>Conclusions</h2><p>Impact loads are the most likely to result in injury to articular cartilage. Having well-developed muscles decreases the loading on the cartilage and thus has a protective effect. Animal research suggests that exercise—at least when done in the form of running—is not harmful to normal joints even under high loads and over long distances. In contrast, similar exercise of an injured joint leads to arthritic change. The literature suggests that in humans, athletic activity is associated with a slightly increased risk of osteoarthritis. Athletic individuals seem to tolerate similar radiographic levels of osteoarthritis with less disability than nonathletic individuals. Joint injury is the primary factor that increases the risk of arthritis developing in athletes.</p></blockquote><p></p>
[QUOTE="BigTex, post: 221079, member: 43589"] Since this subject came up, does being an athlete lead to osteoarthritis or is this perhaps due to injury, genetic factors, age? Remember 60% of people over the age of 50 end up with having problems to some degree. So does bodybuilding and powerlifting really cause osteoarthritis? Sandmeier, Robert H.[b] “Osteoarthritis and Exercise: Does Increased Activity Wear Out Joints?.”[/b] [I]The Permanente Journal[/I] vol. 4,4 (2000): 26–28. Full study [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/[/URL] Several authors have attempted to differentiate between weightbearing and nonweightbearing activity. Sohn and Micheli[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b15-permj-4-4-26']15[/URL] attempted to control for the effect of weightbearing exercise by comparing 504 former college runners with 287 swimmers and found no difference in the incidence of osteoarthritis. Kujala et al[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26']16[/URL] found radiographic signs of osteoarthritis in 3% of the shooters studied, 29% of the soccer players, 31% of the weightlifters, and 14% of the runners. The authors[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26']16[/URL] felt that the majority of the differences in the incidence of osteoarthritis could be explained by the higher rate of injury in soccer players and by increased body weight in weightlifters.[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26']16[/URL] Knee injuries resulted in a fivefold increased risk of osteoarthritis.[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b16-permj-4-4-26']16[/URL] Kujala et al[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b17-permj-4-4-26']17[/URL] also reported on 2049 athletes who competed in the Olympic Games from 1920 to 1965, comparing the athletes with 1403 matched controls. In this study, the endpoint (presenting for joint replacement) takes into account symptoms as well as radiographic criteria. Endurance athletes (runners) had a relative risk of 1.73, participants in mixed-type sports (ex-soccer players) had a relative risk of 1.9, and participants in power sports (weightlifting, wrestling) had a relative risk of 2.17.[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220608/#b17-permj-4-4-26']17[/URL] Incidence of injury was not reported. [HEADING=1]Conclusions[/HEADING] Impact loads are the most likely to result in injury to articular cartilage. Having well-developed muscles decreases the loading on the cartilage and thus has a protective effect. Animal research suggests that exercise—at least when done in the form of running—is not harmful to normal joints even under high loads and over long distances. In contrast, similar exercise of an injured joint leads to arthritic change. The literature suggests that in humans, athletic activity is associated with a slightly increased risk of osteoarthritis. Athletic individuals seem to tolerate similar radiographic levels of osteoarthritis with less disability than nonathletic individuals. Joint injury is the primary factor that increases the risk of arthritis developing in athletes. [/QUOTE]
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Osteoarthritis and adding nandrolone to TRT
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