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Comparison of Jatenzo, Kyzatrex, and Tlando
Overview
Jatenzo, Kyzatrex, and Tlando are all oral testosterone undecanoate (TU) formulations used for testosterone replacement therapy (TRT) in men with hypogonadism. These medications offer an alternative to traditional intramuscular injections and topical gels, providing a more convenient oral administration route.
Mechanism of Action
All three drugs work by replacing the testosterone that is not being produced naturally by the body. They are metabolized through the lymphatic system, which helps avoid liver toxicity, a significant issue with earlier oral testosterone formulations.
Dosage and Administration
Jatenzo: The recommended starting dose is 237 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 158 mg to 396 mg twice daily.
Kyzatrex: The starting dose is 200 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 100 mg once daily to 400 mg twice daily.
Tlando: The recommended dose is 225 mg taken orally twice daily with food. Unlike Jatenzo and Kyzatrex, Tlando does not require dose adjustments.
Efficacy
Jatenzo: In clinical trials, Jatenzo achieved eugonadal testosterone levels in 87% of participants. It has shown significant improvements in sexual and mood symptoms, bone mineral density, and lean body mass.
Kyzatrex: In a phase III trial, 96.1% of participants achieved normal testosterone levels after 90 days. The drug was well-tolerated, with no serious adverse events reported.
Tlando: Approximately 80% of subjects attained testosterone levels within the eugonadal range in clinical studies. Tlando has also shown beneficial effects on sexual and mood symptoms.
Side Effects
Jatenzo: Common side effects include gastrointestinal reactions (nausea, diarrhea) and a small but significant increase in systolic blood pressure (4.9 mmHg).
Kyzatrex: The most notable side effect is a slight increase in systolic blood pressure (1.7 mmHg). No serious adverse events were observed in the study.
Tlando: Similar to Jatenzo, Tlando has been associated with increases in blood pressure and prolactin levels. The mean increase in systolic blood pressure was 3.8 mmHg.
Cost and Insurance
The cost and insurance coverage for these medications can vary. All three drugs are prescription-only and may present a barrier for some patients due to cost and lack of insurance coverage.
Conclusion
Jatenzo, Kyzatrex, and Tlando offer effective and convenient oral options for testosterone replacement therapy. Each has its own dosing regimen and side effect profile, but all have shown to be effective in achieving normal testosterone levels in hypogonadal men. The choice between these medications may depend on individual patient needs, side effect tolerance, and cost considerations.

Citations:
[1] Jatenzo vs Tlando Comparison - Drugs.com
[2] Oral Drugs Offer New Option for Testosterone Replacement
[3] A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product
[4] Oral Testosterone Replacement Therapy: What’s Available and What Took so Long? - American Urological Association
[5] Kyzatrex vs Tlando Comparison - Drugs.com
[6] https://www.goodrx.com/classes/androgens/oral-testosterone-vs-injection
[7] https://www.liebertpub.com/doi/full/10.1089/andro.2022.0011
[8] Testosterone oral agents (JATENZO, TLANDO) - www.westernhealth.com
[9] Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations
[10] A Review of Testosterone Therapy Options for Men
[11] https://www.touchendocrinology.com/general-endocrinology/journal-articles/testosterone-replacement-therapy-a-narrative-review-with-a-focus-on-new-oral-formulations/
[12] https://liebertpub.com/doi/full/10.1089/andro.2021.0025
[13] Testosterone Update on Oral Products

<blockquote data-quote="Nelson Vergel" data-source="post: 282292" data-attributes="member: 3"><p><h2>Comparison of Jatenzo, Kyzatrex, and Tlando</h2><h2>Overview</h2><p>Jatenzo, Kyzatrex, and Tlando are all oral testosterone undecanoate (TU) formulations used for testosterone replacement therapy (TRT) in men with hypogonadism. These medications offer an alternative to traditional intramuscular injections and topical gels, providing a more convenient oral administration route.</p><h2>Mechanism of Action</h2><p>All three drugs work by replacing the testosterone that is not being produced naturally by the body. They are metabolized through the lymphatic system, which helps avoid liver toxicity, a significant issue with earlier oral testosterone formulations.</p><h2>Dosage and Administration</h2>
<ul>
<li data-xf-list-type="ul"><strong>Jatenzo</strong>: The recommended starting dose is 237 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 158 mg to 396 mg twice daily.</li>
<li data-xf-list-type="ul"><strong>Kyzatrex</strong>: The starting dose is 200 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 100 mg once daily to 400 mg twice daily.</li>
<li data-xf-list-type="ul"><strong>Tlando</strong>: The recommended dose is 225 mg taken orally twice daily with food. Unlike Jatenzo and Kyzatrex, Tlando does not require dose adjustments.</li>
</ul><h2>Efficacy</h2>
<ul>
<li data-xf-list-type="ul"><strong>Jatenzo</strong>: In clinical trials, Jatenzo achieved eugonadal testosterone levels in 87% of participants. It has shown significant improvements in sexual and mood symptoms, bone mineral density, and lean body mass.</li>
<li data-xf-list-type="ul"><strong>Kyzatrex</strong>: In a phase III trial, 96.1% of participants achieved normal testosterone levels after 90 days. The drug was well-tolerated, with no serious adverse events reported.</li>
<li data-xf-list-type="ul"><strong>Tlando</strong>: Approximately 80% of subjects attained testosterone levels within the eugonadal range in clinical studies. Tlando has also shown beneficial effects on sexual and mood symptoms.</li>
</ul><h2>Side Effects</h2>
<ul>
<li data-xf-list-type="ul"><strong>Jatenzo</strong>: Common side effects include gastrointestinal reactions (nausea, diarrhea) and a small but significant increase in systolic blood pressure (4.9 mmHg).</li>
<li data-xf-list-type="ul"><strong>Kyzatrex</strong>: The most notable side effect is a slight increase in systolic blood pressure (1.7 mmHg). No serious adverse events were observed in the study.</li>
<li data-xf-list-type="ul"><strong>Tlando</strong>: Similar to Jatenzo, Tlando has been associated with increases in blood pressure and prolactin levels. The mean increase in systolic blood pressure was 3.8 mmHg.</li>
</ul><h2>Cost and Insurance</h2><p>The cost and insurance coverage for these medications can vary. All three drugs are prescription-only and may present a barrier for some patients due to cost and lack of insurance coverage.</p><h2>Conclusion</h2><p>Jatenzo, Kyzatrex, and Tlando offer effective and convenient oral options for testosterone replacement therapy. Each has its own dosing regimen and side effect profile, but all have shown to be effective in achieving normal testosterone levels in hypogonadal men. The choice between these medications may depend on individual patient needs, side effect tolerance, and cost considerations.</p><p></p><p></p><p>Citations:</p><p>[1] <a href="https://www.drugs.com/compare/jatenzo-vs-tlando" target="_blank">Jatenzo vs Tlando Comparison - Drugs.com</a></p><p>[2] <a href="https://consultqd.clevelandclinic.org/oral-medication-offers-new-option-for-testosterone-replacement" target="_blank">Oral Drugs Offer New Option for Testosterone Replacement</a></p><p>[3] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11008350/" target="_blank">A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product</a></p><p>[4] <a href="https://auanews.net/issues/articles/2023/september-extra-2023/oral-testosterone-replacement-therapy-whats-available-and-what-took-so-long" target="_blank">Oral Testosterone Replacement Therapy: What’s Available and What Took so Long? - American Urological Association</a></p><p>[5] <a href="https://www.drugs.com/compare/kyzatrex-vs-tlando" target="_blank">Kyzatrex vs Tlando Comparison - Drugs.com</a></p><p>[6] <a href="https://www.goodrx.com/classes/androgens/oral-testosterone-vs-injection" target="_blank">https://www.goodrx.com/classes/androgens/oral-testosterone-vs-injection</a></p><p>[7] <a href="https://www.liebertpub.com/doi/full/10.1089/andro.2022.0011" target="_blank">https://www.liebertpub.com/doi/full/10.1089/andro.2022.0011</a></p><p>[8] <a href="https://www.westernhealth.com/provider/prior-authorization-criteria/testosterone-oral-agents-jatenzo-tlando/" target="_blank">Testosterone oral agents (JATENZO, TLANDO) - www.westernhealth.com</a></p><p>[9] <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835814/" target="_blank">Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations</a></p><p>[10] <a href="https://www.uspharmacist.com/article/a-review-of-testosterone-therapy-options-for-men" target="_blank">A Review of Testosterone Therapy Options for Men</a></p><p>[11] <a href="https://www.touchendocrinology.com/general-endocrinology/journal-articles/testosterone-replacement-therapy-a-narrative-review-with-a-focus-on-new-oral-formulations/" target="_blank">https://www.touchendocrinology.com/general-endocrinology/journal-articles/testosterone-replacement-therapy-a-narrative-review-with-a-focus-on-new-oral-formulations/</a></p><p>[12] <a href="https://liebertpub.com/doi/full/10.1089/andro.2021.0025" target="_blank">https://liebertpub.com/doi/full/10.1089/andro.2021.0025</a></p><p>[13] <a href="https://grandroundsinurology.com/testosterone-update-on-oral-products/" target="_blank">Testosterone Update on Oral Products</a></p></blockquote><p></p>

[QUOTE="Nelson Vergel, post: 282292, member: 3"] [HEADING=1]Comparison of Jatenzo, Kyzatrex, and Tlando[/HEADING] [HEADING=1]Overview[/HEADING] Jatenzo, Kyzatrex, and Tlando are all oral testosterone undecanoate (TU) formulations used for testosterone replacement therapy (TRT) in men with hypogonadism. These medications offer an alternative to traditional intramuscular injections and topical gels, providing a more convenient oral administration route. [HEADING=1]Mechanism of Action[/HEADING] All three drugs work by replacing the testosterone that is not being produced naturally by the body. They are metabolized through the lymphatic system, which helps avoid liver toxicity, a significant issue with earlier oral testosterone formulations. [HEADING=1]Dosage and Administration[/HEADING] [LIST] [*][B]Jatenzo[/B]: The recommended starting dose is 237 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 158 mg to 396 mg twice daily. [*][B]Kyzatrex[/B]: The starting dose is 200 mg taken orally twice daily with food. The dosage can be adjusted based on serum testosterone levels, with a range from 100 mg once daily to 400 mg twice daily. [*][B]Tlando[/B]: The recommended dose is 225 mg taken orally twice daily with food. Unlike Jatenzo and Kyzatrex, Tlando does not require dose adjustments. [/LIST] [HEADING=1]Efficacy[/HEADING] [LIST] [*][B]Jatenzo[/B]: In clinical trials, Jatenzo achieved eugonadal testosterone levels in 87% of participants. It has shown significant improvements in sexual and mood symptoms, bone mineral density, and lean body mass. [*][B]Kyzatrex[/B]: In a phase III trial, 96.1% of participants achieved normal testosterone levels after 90 days. The drug was well-tolerated, with no serious adverse events reported. [*][B]Tlando[/B]: Approximately 80% of subjects attained testosterone levels within the eugonadal range in clinical studies. Tlando has also shown beneficial effects on sexual and mood symptoms. [/LIST] [HEADING=1]Side Effects[/HEADING] [LIST] [*][B]Jatenzo[/B]: Common side effects include gastrointestinal reactions (nausea, diarrhea) and a small but significant increase in systolic blood pressure (4.9 mmHg). [*][B]Kyzatrex[/B]: The most notable side effect is a slight increase in systolic blood pressure (1.7 mmHg). No serious adverse events were observed in the study. [*][B]Tlando[/B]: Similar to Jatenzo, Tlando has been associated with increases in blood pressure and prolactin levels. The mean increase in systolic blood pressure was 3.8 mmHg. [/LIST] [HEADING=1]Cost and Insurance[/HEADING] The cost and insurance coverage for these medications can vary. All three drugs are prescription-only and may present a barrier for some patients due to cost and lack of insurance coverage. [HEADING=1]Conclusion[/HEADING] Jatenzo, Kyzatrex, and Tlando offer effective and convenient oral options for testosterone replacement therapy. Each has its own dosing regimen and side effect profile, but all have shown to be effective in achieving normal testosterone levels in hypogonadal men. The choice between these medications may depend on individual patient needs, side effect tolerance, and cost considerations. Citations: [1] [URL="https://www.drugs.com/compare/jatenzo-vs-tlando"]Jatenzo vs Tlando Comparison - Drugs.com[/URL] [2] [URL="https://consultqd.clevelandclinic.org/oral-medication-offers-new-option-for-testosterone-replacement"]Oral Drugs Offer New Option for Testosterone Replacement[/URL] [3] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11008350/"]A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product[/URL] [4] [URL="https://auanews.net/issues/articles/2023/september-extra-2023/oral-testosterone-replacement-therapy-whats-available-and-what-took-so-long"]Oral Testosterone Replacement Therapy: What’s Available and What Took so Long? - American Urological Association[/URL] [5] [URL="https://www.drugs.com/compare/kyzatrex-vs-tlando"]Kyzatrex vs Tlando Comparison - Drugs.com[/URL] [6] [URL]https://www.goodrx.com/classes/androgens/oral-testosterone-vs-injection[/URL] [7] [URL]https://www.liebertpub.com/doi/full/10.1089/andro.2022.0011[/URL] [8] [URL="https://www.westernhealth.com/provider/prior-authorization-criteria/testosterone-oral-agents-jatenzo-tlando/"]Testosterone oral agents (JATENZO, TLANDO) - www.westernhealth.com[/URL] [9] [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835814/"]Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations[/URL] [10] [URL="https://www.uspharmacist.com/article/a-review-of-testosterone-therapy-options-for-men"]A Review of Testosterone Therapy Options for Men[/URL] [11] [URL]https://www.touchendocrinology.com/general-endocrinology/journal-articles/testosterone-replacement-therapy-a-narrative-review-with-a-focus-on-new-oral-formulations/[/URL] [12] [URL]https://liebertpub.com/doi/full/10.1089/andro.2021.0025[/URL] [13] [URL="https://grandroundsinurology.com/testosterone-update-on-oral-products/"]Testosterone Update on Oral Products[/URL] [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038