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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Oral NONTOXIC Testosterone under review by FDA
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<blockquote data-quote="CoastWatcher" data-source="post: 40089" data-attributes="member: 2624"><p>A general overview of lymphatic, first-pass absorption.</p><p></p><p>Drug transport into the lymphatic vessels of the small intestine</p><p>The intestinal lymphatics—not the blood capillaries—are responsible for the transport of dietary lipids from the intestine back to the general (systemic) circulation. Drugs that are intrinsically lipophilic, or prodrugs that can be modified to be transiently lipophilic, are able to piggyback on this lipid absorption pathway, effectively achieving drug concentrations in the intestinal lymph 10 to 100 times higher than in the blood.</p><p>This unique drug absorption pathway has a number of highly significant benefits. Drug transport via the intestinal lymph circumvents first-pass metabolism in the liver, enhancing the oral bioavailability of drugs with high first-pass metabolism. The intestinal lymphatics channel drug absorption through the largest lymph node in the body, the mesenteric lymph node—a critical 'sensor' in determining whether the body launches an immune response. Drug delivery via the intestinal lymphatics has significant potential for the delivery of drugs, antigens and adjuvants that enhance or suppress immunity or tolerance.</p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 40089, member: 2624"] A general overview of lymphatic, first-pass absorption. Drug transport into the lymphatic vessels of the small intestine The intestinal lymphatics—not the blood capillaries—are responsible for the transport of dietary lipids from the intestine back to the general (systemic) circulation. Drugs that are intrinsically lipophilic, or prodrugs that can be modified to be transiently lipophilic, are able to piggyback on this lipid absorption pathway, effectively achieving drug concentrations in the intestinal lymph 10 to 100 times higher than in the blood. This unique drug absorption pathway has a number of highly significant benefits. Drug transport via the intestinal lymph circumvents first-pass metabolism in the liver, enhancing the oral bioavailability of drugs with high first-pass metabolism. The intestinal lymphatics channel drug absorption through the largest lymph node in the body, the mesenteric lymph node—a critical 'sensor' in determining whether the body launches an immune response. Drug delivery via the intestinal lymphatics has significant potential for the delivery of drugs, antigens and adjuvants that enhance or suppress immunity or tolerance. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Oral NONTOXIC Testosterone under review by FDA
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