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Oral creatine monohydrate supplementation improves brain performance
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<blockquote data-quote="PAUL-E" data-source="post: 44746" data-attributes="member: 13108"><p>I've read it can also help some with depression </p><p>[h=4]OBJECTIVES:[/b]Creatine plays a pivotal role in brain energy homeostasis, and altered cerebral energy metabolism may be involved in the pathophysiology of depression. Oral creatine supplementation may modify brain high-energy phosphate metabolism in depressed subjects.</p><p>[h=4]METHODS:[/b]Eight unipolar and two bipolar patients with treatment-resistant depression were treated for four weeks with 3-5 g/day of creatine monohydrate in an open add-on design. Outcome measures were the Hamilton Depression Rating Scale, Hamilton Anxiety Scale, and Clinical Global Impression scores, recorded at baseline and at weeks 1, 2, 3 and 4.</p><p>[h=4]RESULTS:[/b]One patient improved considerably after one week and withdrew. Both bipolar patients developed hypomania/mania. For the remaining seven patients, all scale scores significantly improved. Adverse reactions were mild and transitory.</p><p>[h=4]CONCLUSIONS:[/b]This small, preliminary, open study of creatine monohydrate suggests a beneficial effect of creatine augmentation in unipolar depression, but possible precipitation of a manic switch in bipolar depression.</p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/17988366" target="_blank">http://www.ncbi.nlm.nih.gov/pubmed/17988366</a></p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340488/" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340488/</a></p></blockquote><p></p>
[QUOTE="PAUL-E, post: 44746, member: 13108"] I've read it can also help some with depression [h=4]OBJECTIVES:[/b]Creatine plays a pivotal role in brain energy homeostasis, and altered cerebral energy metabolism may be involved in the pathophysiology of depression. Oral creatine supplementation may modify brain high-energy phosphate metabolism in depressed subjects. [h=4]METHODS:[/b]Eight unipolar and two bipolar patients with treatment-resistant depression were treated for four weeks with 3-5 g/day of creatine monohydrate in an open add-on design. Outcome measures were the Hamilton Depression Rating Scale, Hamilton Anxiety Scale, and Clinical Global Impression scores, recorded at baseline and at weeks 1, 2, 3 and 4. [h=4]RESULTS:[/b]One patient improved considerably after one week and withdrew. Both bipolar patients developed hypomania/mania. For the remaining seven patients, all scale scores significantly improved. Adverse reactions were mild and transitory. [h=4]CONCLUSIONS:[/b]This small, preliminary, open study of creatine monohydrate suggests a beneficial effect of creatine augmentation in unipolar depression, but possible precipitation of a manic switch in bipolar depression. [URL]http://www.ncbi.nlm.nih.gov/pubmed/17988366[/URL] [URL]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340488/[/URL] [/QUOTE]
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Oral creatine monohydrate supplementation improves brain performance
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