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I did clomid for 4 and a half years.  Started at a custom compounded 15 mg once every 3rd day with .08mg anastrozole once every 4-5 days.  Felt awesome for a long time and cut clomid to 12.5 Mg evey 4th day about 2 years in and then even every 5th day sometimes.  Still felt awesome.  Total T came down from around 800 to mid 600's with the reduced frequency.  Right at the 4 year mark I crashed and had major anxiety issues extremely suddenly, even panic attacks for a few weeks which ive never had. I've since stopped.  Family doc thinks it was clomid.  Consulted a psychiatrist and she thinks it wasn't.  I had tons of major life stress that I'm not going to go into on a forum and so I am to trying to Isolate variables and figure what happened.  I'm sure clomid contributed, but I honestly think it mightve more likely been low estrogen/ estrogen crashes due to the anastrozole.